Morizono T, Ikeda K
Department of Otolaryngology, University of Minnesota Medical School, Minneapolis.
Eur Arch Otorhinolaryngol. 1990;247(1):40-2. doi: 10.1007/BF00240948.
The compound action potential (CAP) of the eighth nerve and the endocochlear potential (EP) were examined in the chinchilla as an animal model when Escherichia coli endotoxin (100 micrograms) was applied to the middle ear cavity. A significant elevation of the CAP threshold at 2, 3, and 4 kHz was observed 48 h after the instillation of endotoxin, but this hearing loss was thought to be caused by a conductive component. No significant change in the CAP threshold was recognized 30 days after instillation. The EP in either period showed no significant difference. These findings indicate that the application of endotoxin at the concentration used in the present study does not cause a cochlear disturbance.
以豚鼠作为动物模型，当向中耳腔注入大肠杆菌内毒素（100微克）时，检测了其第八对脑神经的复合动作电位（CAP）和内淋巴电位（EP）。在内毒素注入后48小时，观察到2、3和4千赫处的CAP阈值显著升高，但这种听力损失被认为是由传导成分引起的。注入30天后，CAP阈值没有明显变化。两个时期的EP均无显著差异。这些发现表明，本研究中使用的内毒素浓度不会引起耳蜗功能紊乱。
