Infectious Diseases, AIDS and Clinical Immunology Research Center, 16 Al, Kazbegi Avenue, Tbilisi 0160, Georgia.
AIDS Res Ther. 2011 Jul 25;8(1):25. doi: 10.1186/1742-6405-8-25.
The aim of this study was to describe the extent of the HIV epidemic among women in the Republic of Georgia and to identify factors associated with HCV co-infection in this population.
All women aged ≥18 years who were diagnosed with HIV between 1989 and 2006 were identified through the National HIV/AIDS surveillance database. Medical records were reviewed for demographic characteristics, risk factors and HCV serostatus. A total of 249 women were identified. Only 4% declared injection drug use (IDU); sex work was reported by 9%. Substantial risk factors were identified among the women's sexual partners, nearly 69% of whom were IDUs, 84% were HIV positive and 66% HCV positive. Seventeen percent of women were seropositive for HCV. Factors significantly associated with HCV seropositivity in bivariate analyses among non-IDU women were partner IDU+ [Prevalence ratio (PR): 4.5 (95% CI: 1.4, 14.2)], and partner HCV+ [PR: 7.2 (95% CI: 1.8, 29.5)].
The HIV epidemic in the Republic of Georgia is closely tied to the IDU community. Evidence-based interventions targeting IDU and partners of IDU are urgently required to halt the spread of the HIV epidemic in the country.
本研究旨在描述格鲁吉亚共和国女性中的 HIV 流行程度，并确定该人群中与 HCV 合并感染相关的因素。
通过国家 HIV/AIDS 监测数据库，确定了所有在 1989 年至 2006 年间被诊断为 HIV 的年龄≥18 岁的女性。查阅了医疗记录以了解人口统计学特征、风险因素和 HCV 血清状况。共确定了 249 名女性。仅有 4%的人声称使用过注射毒品（IDU）；9%的人从事性工作。女性性伴侣中存在大量风险因素，其中近 69%的人使用 IDU，84%的人 HIV 阳性，66%的人 HCV 阳性。17%的女性 HCV 血清呈阳性。在非 IDU 女性的单因素分析中，与 HCV 血清阳性显著相关的因素是伴侣 IDU+[患病率比（PR）：4.5（95%置信区间：1.4，14.2）]和伴侣 HCV+[PR：7.2（95%置信区间：1.8，29.5）]。
格鲁吉亚的 HIV 流行与 IDU 社区密切相关。迫切需要针对 IDU 和 IDU 伴侣的基于证据的干预措施，以阻止该国 HIV 疫情的蔓延。
