Department of Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine and Animal Resources King Faisal University, Postal Code 1757, Al Ahsa 31982, Saudi Arabia. m
Environ Toxicol Pharmacol. 2011 Mar;31(2):333-8. doi: 10.1016/j.etap.2011.01.001. Epub 2011 Jan 18.
The present study aimed at defining the testicular toxicity of propetamphos. Mature male albino rats (5-6 months old) were treated with propetamphos orally at doses of 0, 0.18, 0.38, 0.75, 1.5 and 3mg/kg/day for 60 consecutive days. Propetamphos at a dose of 0.38 mg/kg/day significantly reduced the sperm motility only. At 0.75 mg/kg/day sperm count, sperm motility, plasma testosterone level and activity of sorbiol dehydrogenase (SDH) were significantly reduced and sperm morphological abnormalities were significantly increased. At 1.5mg/kg/day weight of testes, seminal vesicle and epididymis were reduced dose dependently whereas, at 3mg/kg/day, weight of prostate gland and activities of acid phosphatase (ACP) and glucose-6-P-dehydrogenase (G6PDH) were decreased significantly. On histopathological examination indicated toxicity of propetamphos on testes depending on dose and observed at doses higher than 0.38 mg/kg/day. These results indicate testicular toxicity of propetamphos at dose of 0.38 mg/kg/day or higher in male albino rats.
本研究旨在确定丙硫磷的睾丸毒性。成熟雄性白化大鼠（5-6 个月大）经口给予丙硫磷，剂量分别为 0、0.18、0.38、0.75、1.5 和 3mg/kg/天，连续 60 天。丙硫磷 0.38mg/kg/天的剂量仅显著降低精子活力。0.75mg/kg/天剂量时，精子计数、精子活力、血浆睾酮水平和山梨醇脱氢酶（SDH）活性显著降低，精子形态异常显著增加。1.5mg/kg/天剂量时，睾丸、精囊和附睾的重量呈剂量依赖性降低，而 3mg/kg/天剂量时，前列腺重量和酸性磷酸酶（ACP）和葡萄糖-6-磷酸脱氢酶（G6PDH）活性显著降低。组织病理学检查表明丙硫磷对睾丸具有毒性，且在高于 0.38mg/kg/天的剂量下观察到这种毒性。这些结果表明丙硫磷在雄性白化大鼠中具有 0.38mg/kg/天或更高剂量的睾丸毒性。
