Thromboangiitis obliterans (Bürger's disease) in a woman--a case report and review of the literature.

We report the case of a 43-year-old woman, a longstanding heavy cigarette smoker, who developed Bürger's disease, leading to mid-thigh amputation of her left leg. After she gave up smoking her disease was arrested but Raynaud's phenomenon continues to affect her hands and right foot. In reviewing the literature, we found only 25 previous well-documented cases of Bürger's disease occurring in females that would satisfy clinical, angiographic and histological criteria to make this diagnosis probable.