合成衍生自胆酸的双硫代氨基甲酸铵的两种离子物种。

Synthesis of both ionic species of ammonium dithiocarbamate derived cholic acid moieties.

机构信息

Department of Chemistry, FI-40014 University of Jyväskylä, Finland.

出版信息

Molecules. 2011 Jul 26;16(8):6306-12. doi: 10.3390/molecules16086306.

DOI:10.3390/molecules16086306

PMID:21792148

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6264747/

Abstract

The reaction of 3-aminopropylamide of cholic acid with CS₂ produced a bile acid derivative of dithiocarbamic acid which further formed an ammonium salt with another molecule of 3-aminopropylamide of cholic acid. The cationic 3-ammonium propylamide of cholic acid did not react further with CS₂ and the formed salt was stable in the reaction mixture, even when excess CS₂ was used. When the reaction was carried out in the presence of aqueous sodium hydroxide, only the bile acid derivative of sodium dithiocarbamate was formed. The dithiocarbamate derivatives were characterized by ¹H- and ¹³C-NMR spectroscopy and ESI-TOF mass spectrometry.

摘要

胆酸 3-氨丙酰胺与 CS₂ 的反应生成了二硫代氨基甲酸盐的胆酸衍生物，该衍生物进一步与另一个胆酸 3-氨丙酰胺分子形成了铵盐。阳离子胆酸 3-氨丙酰胺与 CS₂ 不再进一步反应，形成的盐在反应混合物中很稳定，即使使用过量的 CS₂ 也是如此。当反应在氢氧化钠存在下进行时，仅形成了二硫代氨基甲酸盐的胆酸衍生物。通过 ¹H 和 ¹³C-NMR 光谱以及 ESI-TOF 质谱对二硫代氨基甲酸盐衍生物进行了表征。