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[多关节化脓性关节炎:19例分析]

[Polyarticular septic arthritis: analysis of 19 cases].

作者信息

Mateo Soria Lourdes, Olivé Marqués Alejandro, García Casares Elisabet, García Melchor Emma, Holgado Pérez Susana, Tena Marsà Xavier

机构信息

Sección de Reumatología, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, España.

出版信息

Reumatol Clin. 2009 Feb;5(1):18-22. doi: 10.1016/S1699-258X(09)70199-8. Epub 2009 Feb 28.

Abstract

OBJECTIVE

Polyarticular septic arthritis accounts for 15% of all septic arthritis, but there are few references in the literature. We describe characteristics of patients with polyarticular septic arthritis in a rheumatology service.

PATIENTS AND METHOD

Retrospective analysis of patients with septic arthritis involving more than one joint. Only patients with positive culture of synovial fluid were included. Clinical, analytical and radiological variables are reviewed.

RESULTS

19 patients (14 male) had a polyarticular infection. Mean age was 55 years. Mean time from onset to diagnosis was 6 days. The knee was the most commonly involved joint, followed by ankle. The mean number of joints involved per patient was 3. Risk factors included diabetes, chronic renal or hepatic disease, gout and rheumatoid arthritis. Most commonly isolated agents were S. aureus (47%) and S. agalactiae (21%). Blood cultures were positive in 52,6% and 15.8% had septic shock. Scintygraphic bone scan showed a polyarticular uptake. Mean duration of antibiotic therapy was 46±27 days. Clinical outcome was good in 52,6%, complicated in 26%, and mortality rate was 15.8% (3 cases). Joint debridement was performed in 21%.

CONCLUSIONS

Multiple joint involvement does not exclude the diagnosis of septic arthritis. Inflammatory arthritis is an important risk factor. S. aureus in the main infectious agent. The morbidity and mortality of this condition are important, so we need to maintain a high index of suspicion for the condition.

摘要

目的

多关节化脓性关节炎占所有化脓性关节炎的15%,但文献中相关参考较少。我们描述了风湿病科服务中多关节化脓性关节炎患者的特征。

患者与方法

对累及一个以上关节的化脓性关节炎患者进行回顾性分析。仅纳入滑膜液培养阳性的患者。对临床、分析和放射学变量进行了回顾。

结果

19例患者(14例男性)发生多关节感染。平均年龄为55岁。从发病到诊断的平均时间为6天。膝关节是最常受累的关节,其次是踝关节。每位患者受累关节的平均数量为3个。危险因素包括糖尿病、慢性肾或肝病、痛风和类风湿关节炎。最常分离出的病原体是金黄色葡萄球菌(47%)和无乳链球菌(21%)。血培养阳性率为52.6%,15.8%的患者发生感染性休克。骨闪烁扫描显示多关节摄取。抗生素治疗的平均持续时间为46±27天。52.6%的患者临床结局良好,26%的患者病情复杂,死亡率为15.8%(3例)。21%的患者进行了关节清创术。

结论

多关节受累并不排除化脓性关节炎的诊断。炎性关节炎是一个重要的危险因素。金黄色葡萄球菌是主要的感染病原体。这种疾病的发病率和死亡率较高,因此我们需要对该疾病保持高度的怀疑指数。

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