University of Aberdeen, Aberdeen Fungal Group, Section of Immunity and Infection, Institute of Medical Sciences, Aberdeen AB25 2ZD, Scotland, United Kingdom.
Curr Opin Microbiol. 2011 Aug;14(4):392-9. doi: 10.1016/j.mib.2011.07.001. Epub 2011 Jul 29.
Dectin-1 is an innate immune pattern recognition receptor (PRR) that, through its ability to bind β-glucans, is involved in the recognition of several pathogenic fungi. Dectin-1 can stimulate a variety of cellular responses via the Syk/CARD9 signalling pathway, including phagocytosis, cytokine production and the respiratory burst. Several advances in our understanding of Dectin-1 immunobiology have been made in recent years, including characterisation of additional signalling pathways and demonstration of its ability to directly induce the development of adaptive immunity. However, the physiological role of many of the functions of this receptor is still unclear. This review aims to provide an update on Dectin-1 and its role within antifungal immune responses, focussing on progress made in the last two years.
Dectin-1 是一种先天免疫模式识别受体 (PRR)，通过其结合β-葡聚糖的能力，参与识别几种致病性真菌。Dectin-1 通过 Syk/CARD9 信号通路刺激多种细胞反应，包括吞噬作用、细胞因子产生和呼吸爆发。近年来，我们对 Dectin-1 免疫生物学的理解取得了一些进展，包括鉴定了其他信号通路，并证明了其能够直接诱导适应性免疫的发展。然而，该受体的许多功能的生理作用仍不清楚。本文综述了 Dectin-1 及其在抗真菌免疫反应中的作用，重点介绍了过去两年的进展。
