Institute of Pharmaceutical Sciences, Musashino University, Nishi-Tokyo, Tokyo 202–8585, Japan.
Biol Pharm Bull. 2011;34(8):1215-8. doi: 10.1248/bpb.34.1215.
Zinc-containing β-tricalcium phosphate (ZnTCP) nano particles were injected into zinc-deficient rats to promote osteogenesis. Sprague-Dawley (SD) rats (4 weeks old, average weight of 70 g) were divided into four groups: Normal rats (not ovariectomized (OVX)), Control rats (OVX), and OVX rats injected with a suspension of ZnTCP nano particles or ZnSO(4). The ZnTCP contained 6.17% zinc. The suspensions (0.6 mg as a zinc volume/0.2 ml) were injected around the jaw bone once a week for 12 weeks. Local effects on the bone mineral content (BMC) of jawbone, and systemic effects on body weight, the BMC of both femurs determined by X-ray computed tomography, and bone mechanical strength (BMS) measured by the three-point bending method, were examined. The BMC of jaw bone was significantly higher in the ZnTCP-treated group than un-treated or ZnSO(4)-treated group. Body weight, the BMC of femurs, and BMS were also significantly higher in the ZnTCP treated-group. The zinc-containing β-tricalcium phosphate nano particles were effective at preventing bone loss induced by ovariectomy in rats and have potential uses for treating periodontitis.
含锌β-磷酸三钙（ZnTCP）纳米颗粒被注射到缺锌的大鼠体内以促进成骨作用。Sprague-Dawley（SD）大鼠（4 周龄，平均体重 70g）分为四组：正常大鼠（未去卵巢（OVX））、对照大鼠（OVX）和注射 ZnTCP 纳米颗粒或 ZnSO4 悬浮液的 OVX 大鼠。ZnTCP 含有 6.17%的锌。悬浮液（0.6mg 锌体积/0.2ml）每周一次注射到颌骨周围，共 12 周。检测颌骨局部骨矿物质含量（BMC）、全身体重、股骨 BMC（通过 X 射线计算机断层扫描）和骨机械强度（BMS）（三点弯曲法测量）的局部和全身影响。与未处理组或 ZnSO4 处理组相比，ZnTCP 处理组的颌骨 BMC 显著更高。体重、股骨 BMC 和 BMS 也在 ZnTCP 处理组中显著更高。含锌的β-磷酸三钙纳米颗粒可有效预防去卵巢大鼠的骨丢失，具有治疗牙周炎的潜力。
