Division of Medical Oncology, University of Colorado at Denver, University of Colorado Cancer Center, Aurora, CO 80045, USA.
Semin Oncol. 2011 Aug;38(4):588-97. doi: 10.1053/j.seminoncol.2011.05.013.
Colorectal cancer (CRC) is one of the most common cancers and causes of cancer death in the world despite incremental improvement in the treatment of this disease. Advancements in the molecular understanding of CRC have led to new areas of therapeutic research. In this endeavor, numerous compounds with specific molecular targets are being developed in preclinical and early clinical studies. Molecular pathways involved in CRC and potentially effective targeted agents in development will be reviewed.
结直肠癌(CRC)是世界上最常见的癌症之一,也是癌症死亡的主要原因之一。尽管这种疾病的治疗方法有所改进,但仍有很大的提升空间。对 CRC 的分子认识的提高导致了治疗研究的新领域。在这方面,许多具有特定分子靶点的化合物正在进行临床前和早期临床研究。本文将对 CRC 涉及的分子途径和正在开发的潜在有效的靶向药物进行综述。