1. Armed Forces Institute of Pathology and American Registry of Pathology, Washington, DC, USA.
J Cancer. 2011;2:401-12. doi: 10.7150/jca.2.401. Epub 2011 Jul 20.
The human breast lobular and ductal structures and the derived tumors from these structures differ substantial in their morphology, microenvironment, biological presentation, functions, and clinical prognosis. Based on these differences, we have proposed that pre-invasive lobular tumors may progress to invasive lesions through "in situ malignant transformation", in which the entire myoepithelial cell layer within a given lobule or lobular clusters undergoes extensive degeneration and disruptions, which allows the entire epithelial cell population associated with these myoepithelial cell layers directly invade the stroma or vascular structures. In contrast, pre-invasive ductal tumors may invade the stroma or vascular structures through "progenitor-mediated cell budding", in which focal myoepithelial cell degeneration-induced aberrant leukocyte infiltration causes focal disruptions in the tumor capsules, which selectively favor monoclonal proliferation of the overlying tumor stem cells or a biologically more aggressive cell clone. Our current study attempted to provide more direct morphological and immunohistochemical data that are consistent with our hypotheses.
人类乳腺小叶和导管结构及其衍生的肿瘤在形态、微环境、生物学表现、功能和临床预后方面存在显著差异。基于这些差异，我们提出，浸润前小叶肿瘤可能通过“原位恶性转化”进展为浸润性病变，在此过程中，给定小叶或小叶簇内的整个肌上皮细胞层发生广泛退化和破坏，从而使与这些肌上皮细胞层相关的整个上皮细胞群直接浸润基质或血管结构。相比之下，浸润前导管肿瘤可能通过“祖细胞介导的细胞芽生”侵犯基质或血管结构，其中局灶性肌上皮细胞退化诱导的异常白细胞浸润导致肿瘤包膜的局灶性破坏，这选择性地有利于覆盖其上的肿瘤干细胞或生物学上更具侵袭性的细胞克隆的单克隆增殖。我们目前的研究试图提供更直接的形态学和免疫组织化学数据，这些数据与我们的假说一致。
