Mariani Aude, Jeandel C, Paris F, Ecochard R
Service de Pédiatrie 1, Centre Hopitalo-Universitaire Arnaud de Villeneuve, Montpellier, France.
J Pediatr Endocrinol Metab. 2011;24(5-6):319-25. doi: 10.1515/jpem.2011.031.
As the prognosis for final height is unfavorable for children with idiopathic short stature (ISS), we studied the pubertal growth dynamics in these children, which is a determinant factor in final height.
SUBJECTS/METHODS: In a retrospective cohort study, we analyzed the pubertal period, age of puberty and peripubertal growth in 50 children with ISS.
The onset of puberty occurred later. Growth rate tended to become increasingly subnormal in the prepubertal period and height was -2.45 SD at puberty onset. Growth reaccelerated at this point, which tended to correct the deviation from the mean height, but it was insufficient to obtain a normal final height.
The dynamics of growth in children with ISS showed a distinct pattern in the prepubertal and pubertal periods and puberty is significantly delayed in this population. These patterns could explain the unfavorable prognosis for children with ISS.
由于特发性身材矮小（ISS）儿童的最终身高预后不佳，我们研究了这些儿童的青春期生长动态，这是最终身高的一个决定性因素。
对象/方法：在一项回顾性队列研究中，我们分析了50例ISS儿童的青春期、青春期年龄和青春期周围生长情况。
青春期开始较晚。青春期前生长速率趋于越来越低于正常水平，青春期开始时身高为-2.45标准差。此时生长加速，这倾向于纠正与平均身高的偏差，但不足以获得正常的最终身高。
ISS儿童的生长动态在青春期前和青春期表现出明显的模式，且该人群青春期明显延迟。这些模式可以解释ISS儿童预后不佳的原因。
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