Department of Developmental Epileptology, Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, CZ-14220,Prague, Czech Republic.
Brain Res. 2011 Sep 15;1412:102-7. doi: 10.1016/j.brainres.2011.07.034. Epub 2011 Jul 23.
The role of inhibitory γ-aminobutyric acid-A (GABA-A) system in the cortical epileptic afterdischarges (ADs) was studied at three different developmental stages of rats. Animals 12, 18 and 25days old with implanted epidural electrodes were pretreated with bicuculline (1 and 2mg/kgi.p.) and 15min later repeatedly stimulated with low frequency trains with stepwise increasing current intensity. Bicuculline only exceptionally decreased threshold current intensities necessary for elicitation of movements directly bound to stimulation, spike-and wave ADs, clonic seizures and transition into a limbic type of ADs. Duration of ADs was not systematically affected by either dose of bicuculline. In contrast, transcallosal evoked potentials exhibited under the influence of bicuculline steeper curve expressing relation between intensity of stimuli and amplitude of responses. In contrast to GABA-B receptors, GABA-A receptors do not play an important role in generation and arrest of cortical epileptic ADs in immature rats.
研究了抑制性γ-氨基丁酸-A（GABA-A）系统在大鼠三个不同发育阶段皮层癫痫发作后（ADs）中的作用。植入硬膜外电极的 12、18 和 25 日龄动物接受荷包牡丹碱（1 和 2mg/kg，i.p.）预处理，15min 后用逐渐增加电流强度的低频电刺激重复刺激。荷包牡丹碱仅偶尔降低与刺激直接相关的运动、棘波和尖波 ADs、阵挛性发作和向边缘型 ADs 转变所需的阈电流强度。ADs 的持续时间不受荷包牡丹碱任何剂量的系统影响。相比之下，在荷包牡丹碱的影响下，经胼胝体诱发的电位表现出更陡峭的曲线，该曲线表达了刺激强度与反应幅度之间的关系。与 GABA-B 受体不同，GABA-A 受体在未成熟大鼠的皮质癫痫 ADs 的产生和终止中不起重要作用。
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