Department of Biology, University of Copenhagen, Copenhagen, Denmark.
PLoS One. 2011;6(8):e22893. doi: 10.1371/journal.pone.0022893. Epub 2011 Aug 4.
Previous studies have concluded that the development of polydipsia (PD, a daily water intake ≥ 21 ml) among captive Danish bank voles, is associated with the development of a type 1 diabetes (T1D), based on findings of hyperglycaemia, glucosuria, ketonuria/-emia, lipemia, destroyed beta cells, and presence of autoantibodies against GAD65, IA-2, and insulin.
We retrospectively analysed data from two separate colonies of Danish bank voles in order to 1) estimate survivorship after onset of PD, 2) evaluate whether the weight of PD voles differed from non-PD voles, and, 3), evaluate a state of PD as a practical and non-invasive tool to screen for voles with a high probability of hypeglycaemia. In addition, we discuss regional differences related to the development of diabetes in Scandinavian bank voles and the relevance of the Ljungan virus as proposed etiological agent.
We found that median survival after onset of PD is at least 91 days (lower/upper quartiles = 57/134 days) with a maximum recording of at least 404 days survivorship. The development of PD did not influence the weight of Danish bank voles. The measures of accuracy when using PD as predictor of hyperglycaemia, i.e. sensitivity, specificity, positive predictive value, and negative predictive value, equalled 69%, 97%, 89%, and 89%, respectively.
The relatively long survival of Danish PD bank voles suggests potentials for this model in future studies of the long-term complications of diabetes, of which some observations are mentioned. Data also indicates that diabetes in Danish bank is not associated with a higher body weight. Finally, the method of using measurements of daily water intake to screen for voles with a high probability of hyperglycaemia constitutes a considerable refinement when compared to the usual, invasive, methods.
先前的研究得出结论，在丹麦田鼠中，多饮症（PD，每日水摄入量≥21 毫升）的发展与 1 型糖尿病（T1D）的发展有关，这是基于高血糖、糖尿、酮尿/血症、脂血症、β细胞破坏以及存在针对 GAD65、IA-2 和胰岛素的自身抗体的发现。
我们回顾性分析了来自两个丹麦田鼠独立群体的数据，以 1）估计 PD 发病后的存活率，2）评估 PD 田鼠的体重是否与非 PD 田鼠的体重不同，以及 3）评估 PD 状态作为筛选高血糖可能性大的田鼠的实用和非侵入性工具。此外，我们讨论了与斯堪的纳维亚田鼠糖尿病发展相关的区域差异以及 Ljungan 病毒作为提出的病因因子的相关性。
我们发现，PD 发病后的中位存活时间至少为 91 天（下/上四分位数=57/134 天），最长记录的存活时间至少为 404 天。PD 的发展并没有影响丹麦田鼠的体重。PD 作为预测高血糖的指标的准确性测量值，即敏感性、特异性、阳性预测值和阴性预测值，分别为 69%、97%、89%和 89%。
丹麦 PD 田鼠的相对较长的存活时间表明该模型在未来糖尿病长期并发症研究中具有潜力，其中一些观察结果被提及。数据还表明，丹麦田鼠的糖尿病与更高的体重无关。最后，与常规的、侵入性的方法相比，使用每日水摄入量测量值来筛选高血糖可能性大的田鼠的方法是一个相当大的改进。
