18F-FP-(+)-DTBZ（18F-AV-133）累积摄取测量的最佳扫描时间窗。
Optimal scanning time window for 18F-FP-(+)-DTBZ (18F-AV-133) summed uptake measurements.
机构信息
Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
出版信息
Nucl Med Biol. 2011 Nov;38(8):1149-55. doi: 10.1016/j.nucmedbio.2011.05.010. Epub 2011 Aug 9.
UNLABELLED
(18)F-9-fluoropropyl-(+)-dihydrotetrabenazine ((18)F-AV-133) is a novel positron emission tomography tracer for imaging the vesicular monoamine transporter II in dopaminergic neuron degeneration, which might be indicative for Parkinson's disease (PD) and other parkinsonism. Studies were performed to optimize the imaging time window for calculating standardized uptake value ratio (SUVR) with correlation to distribution volume ratio (DVR) and in differentiating PD from normal controls (NCs).
METHODS
Thirteen (18)F-AV-133 positron emission tomography studies were conducted on four NCs (age, 62.3±4.9 years) and nine PD patients (age, 60.8±6.0 years) with Hoehn and Yahr stages 2 to 3. Dynamic images were acquired within 180 min (0-30, 50-140 and 160-180 min) and were rearranged into 14 of 10-min scans. The contralateral striatum was defined as the opposite striatum to the predominantly affected limbs. Volumes of interest (VOIs) of bilateral putamen, caudate nuclei and occipital cortex (OC; as the reference region) were delineated from individual magnetic resonance imaging. SUVRs of striatum to OC were computed from 14 dynamic image sets. The DVRs were computed from Logan graphic analysis by using OC as the input. The performance of SUVR was evaluated based on the correlation of SUVR at each time window to DVR, as well as the Cohen effect size (group mean SUVR difference between PD and NC/standard deviation).
RESULTS
(18)F-AV-133 uptake decreased in PD subjects at bilateral striatum especially at contralateral side with posterior putamen predominant as compared with NC. Consistent higher correlations of SUVRs to DVR for all VOIs were observed at later time window and reached to its maximal value of 0.9917 at 90-100 min. The group mean SUVR differences between NC and PD subjects increased and reached relatively stable values after 90 min. The effect sizes for all VOIs were stable across different time window and with the largest value around 90~120 min.
CONCLUSION
The scanning time of 90-100 min for (18)F-AV-133 is considered as the optimal time window for summed uptake measurements in terms of SUVRs' correlation to DVRs, differential power, stability and clinical feasibility across and between NC and PD patients.
目的
（18）F-9-氟丙基-（+）-二氢四苯并嗪（（18）F-AV-133）是一种新型的正电子发射断层扫描示踪剂，用于成像囊泡单胺转运体 II 在多巴胺能神经元变性中的作用，这可能提示帕金森病（PD）和其他帕金森综合征。本研究旨在优化成像时间窗，以计算标准化摄取值比（SUVR）与分布容积比（DVR）的相关性，并区分 PD 与正常对照（NC）。
方法
对 4 名 NC（年龄 62.3±4.9 岁）和 9 名 PD 患者（年龄 60.8±6.0 岁，Hoehn 和 Yahr 分期 2-3 期）进行了 13 次（18）F-AV-133 正电子发射断层扫描研究。在 180 分钟内（0-30、50-140 和 160-180 分钟）采集动态图像，并将其重新排列为 14 个 10 分钟扫描。对侧纹状体定义为与主要受累肢体相对的对侧纹状体。从个体磁共振成像中描绘双侧壳核、尾状核和枕叶皮质（OC；作为参考区域）的感兴趣区（VOIs）。从 14 个动态图像集中计算纹状体到 OC 的 SUVR。通过使用 OC 作为输入，通过 Logan 图形分析计算 DVR。基于每个时间窗的 SUVR 与 DVR 的相关性，以及 Cohen 效应大小（PD 与 NC 之间的组平均 SUVR 差异/标准差），评估 SUVR 的性能。
结果
与 NC 相比，PD 患者双侧纹状体（尤其是对侧壳核和后壳核）的（18）F-AV-133 摄取减少。在后期时间窗观察到所有 VOI 的 SUVR 与 DVR 的相关性更高，在 90-100 分钟达到最大值 0.9917。NC 和 PD 受试者之间的组平均 SUVR 差异增加，并在 90 分钟后达到相对稳定的值。所有 VOI 的效应大小在不同的时间窗内都是稳定的，最大的效应大小约为 90~120 分钟。
结论
对于（18）F-AV-133，90-100 分钟的扫描时间被认为是 SUVR 与 DVR 的相关性、差异能力、稳定性以及 NC 和 PD 患者之间的临床可行性方面的最佳总摄取测量时间窗。
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