日本人群中糖尿病与卒中及其亚型发病风险的关系：日本公共卫生中心研究。
Diabetes mellitus and risk of stroke and its subtypes among Japanese: the Japan public health center study.
机构信息
Public Health, Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, Osaka, Japan, 2-2 Yamadaoka, Suita-shi, Osaka, 565-0871 Japan.
出版信息
Stroke. 2011 Sep;42(9):2611-4. doi: 10.1161/STROKEAHA.111.614313. Epub 2011 Aug 11.
BACKGROUND AND PURPOSE
Although diabetes mellitus has been recognized as a risk factor for ischemic stroke, evidence is limited for ischemic stroke subtypes among Asians.
METHODS
A survey was conducted of a total of 13 129 men and 22 528 women aged 40 to 69 years at baseline. During the median 12.0-year follow-up, there were 526 incidences of ischemic strokes (259 lacunar infarctions, 91 large-artery occlusive, and 140 embolic infarctions).
RESULTS
The risk of ischemic stroke for both sexes was approximately 2 to 4 times higher for diabetic subjects than for those with normal glucose levels. Significant excess risks of lacunar and embolic infarction for both sexes and of large-artery occlusive infarctions for women were also observed in diabetic subjects. Diabetes mellitus was not associated with risk of intraparenchymal or subarachnoid hemorrhage for either sex.
CONCLUSIONS
Diabetes mellitus is a significant risk factor for ischemic stroke and all subtypes of ischemic stroke for middle-aged Japanese.
背景与目的
尽管糖尿病已被认为是缺血性脑卒中的一个危险因素，但亚洲人群中缺血性脑卒中亚型的证据有限。
方法
对基线时年龄在 40 至 69 岁的 13129 名男性和 22528 名女性进行了一项调查。在中位 12.0 年的随访期间，共发生 526 例缺血性脑卒中（259 例腔隙性梗死、91 例大动脉闭塞性梗死和 140 例栓塞性梗死）。
结果
与血糖正常者相比，糖尿病患者无论男女发生缺血性脑卒中的风险均约为 2 至 4 倍。糖尿病患者无论男女的腔隙性和栓塞性梗死风险以及女性的大动脉闭塞性梗死风险也明显升高。糖尿病与任何性别发生脑实质或蛛网膜下腔出血的风险均无关。
结论
糖尿病是日本中年人群缺血性脑卒中及所有缺血性脑卒中亚型的重要危险因素。
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