通过[123I]间位碘代苄胍心肌闪烁显像和嗅觉试验鉴别帕金森病与多系统萎缩。

Differentiating Parkinson's disease from multiple system atrophy by [123I] meta-iodobenzylguanidine myocardial scintigraphy and olfactory test.

机构信息

Department of Neurology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.

出版信息

Parkinsonism Relat Disord. 2011 Nov;17(9):698-700. doi: 10.1016/j.parkreldis.2011.07.011. Epub 2011 Aug 12.

DOI:10.1016/j.parkreldis.2011.07.011

PMID:21840242

Abstract

We aimed to study whether either [(123)l] myocardial meta-iodobenzylguanidine (MIBG) myocardial scintigraphy or the odor stick identification test for Japanese (OSIT-J) is effective in differentiating Parkinson's disease (PD) from multiple system atrophy (MSA). We compared the MIBG accumulation and olfactory score between 42 PD and 42 MSA (19 MSA-P and 23 MSA-C) patients in the early stages. [(123)l] MIBG myocardial scintigraphy showed higher sensitivity and the olfactory test higher specificity in differentiating PD from MSA. There were significant differences between PD and MSA-C (p = 0.0019) instead of MSA-P (p > 0.05) in the MIBG accumulation, while there were significant differences between PD and MSA-P (p = 0.0003) or MSA-C (p = 0.0003) in the OSIT-J score. Our data suggest that the olfactory test can be useful as a clinical tool with its higher specificity in differentiating PD from MSA in the early stages and, moreover, support the discrimination of PD from MSA-P.

摘要

我们旨在研究 [(123)l] 间碘苄胍（MIBG）心肌闪烁显像或日本嗅觉辨别测试（OSIT-J）是否能有效区分帕金森病（PD）和多系统萎缩（MSA）。我们比较了 42 例早期 PD 和 42 例 MSA（19 例 MSA-P 和 23 例 MSA-C）患者的 MIBG 摄取和嗅觉评分。[(123)l] MIBG 心肌闪烁显像在区分 PD 和 MSA 方面具有更高的敏感性，而嗅觉测试具有更高的特异性。在 MIBG 摄取方面，PD 与 MSA-C 之间存在显著差异（p = 0.0019），而与 MSA-P 之间无显著差异（p > 0.05）；在 OSIT-J 评分方面，PD 与 MSA-P（p = 0.0003）或 MSA-C（p = 0.0003）之间存在显著差异。我们的数据表明，嗅觉测试可能是一种有用的临床工具，在区分早期 PD 和 MSA 方面具有更高的特异性，此外，还支持将 PD 与 MSA-P 区分开来。