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557 例非脊柱骨样骨瘤的射频消融治疗。

Radiofrequency ablation for non-spinal osteoid osteomas in 557 patients.

机构信息

Department of Radiology, University of Bologna, Istituto Ortopedico Rizzoli, Bologna, Italy.

出版信息

Eur Radiol. 2012 Jan;22(1):181-8. doi: 10.1007/s00330-011-2240-1. Epub 2011 Aug 14.

Abstract

OBJECTIVES

To present the results of biopsy and computed tomography (CT) guided radiofrequency ablation (RFA) for non-spinal osteoid osteomas, and compare the results before and after procedural modifications.

METHODS

We retrospectively studied 557 patients with non-spinal osteoid osteomas treated with biopsy and CT-guided RFA. In 68 patients we used 3-mm CT at 2-mm intervals, 19 G/5-mm active tip electrodes, and one 4-minute ablation at 90-93°C. In 489 patients we used contiguous 1-mm CT, 20 G/5-15-mm electrodes, ablation maintaining 60°C for 2 min followed by 14-15 min at 90-93°C, and multiple ablations in the same session for large and multiform lesions.

RESULTS

533/557 patients (96%) remained asymptomatic and 24/557 (4%) had recurrence; repeat RFA was successful in 22/24 patients (92%). Biopsy was non-diagnostic in 82%. With the modifications performed, success improved from 79% to 98%, recurrences reduced from 21% to 2% and complications from 5.9% to 0.2% (p < 0.001). All patients with large and multiform lesions treated with one ablation had recurrence, compared to no patient with similar lesions and multiple ablations in the same session.

CONCLUSION

Electrode parameters, duration of ablation, morphology and size of osteoid osteomas are important for RFA. The above modifications are recommended for improved outcome.

摘要

目的

介绍活检和计算机断层扫描(CT)引导下射频消融(RFA)治疗非脊柱骨样骨瘤的结果,并比较治疗方法修改前后的结果。

方法

我们回顾性研究了 557 例接受活检和 CT 引导下 RFA 治疗的非脊柱骨样骨瘤患者。在 68 例患者中,我们使用 3-mm 层厚、2-mm 间隔的 CT,19G/5mm 活性尖端电极,90-93°C 下单次消融 4 分钟。在 489 例患者中,我们使用连续 1mm CT,20G/5-15mm 电极,消融过程中保持 60°C 2 分钟,然后在 90-93°C 下持续 14-15 分钟,对于大的和多形性病变,在同一治疗过程中进行多次消融。

结果

533/557 例(96%)患者无症状,24/557 例(4%)患者复发;24 例(92%)患者再次接受 RFA 成功。82%的活检结果为非诊断性。经过改进,成功率从 79%提高到 98%,复发率从 21%降低到 2%,并发症发生率从 5.9%降低到 0.2%(p < 0.001)。所有接受单次消融治疗的大的和多形性病变患者均复发,而接受同一治疗过程中多次消融的患者无复发。

结论

电极参数、消融时间、骨样骨瘤的形态和大小是 RFA 的重要因素。建议进行上述改进以获得更好的结果。

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