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[影响显微外科输精管附睾吻合术结果的因素]

[Factors affecting the results of microsurgical vasoepididymostomy].

作者信息

Peng Jing, Yuan Yi-ming, Zhang Zhi-chao, Gao Bing, Song Wei-dong, Xin Zhong-cheng, Guo Ying-lu, Jin Jie

机构信息

Andrology Center, Peking University First Hospital, Beijing 100034 , China.

出版信息

Beijing Da Xue Xue Bao Yi Xue Ban. 2011 Aug 18;43(4):562-4.

Abstract

OBJECTIVE

To evaluate the intraoperative factors affecting the patency of microsurgical vasoepididymostomy.

METHODS

From January 2009 to July 2010, 73 men with obstructive azoospermia had undergone longitudinal intussusception vasoepididymostomy (LIVE). The mean age (range) was 31 years (23 to 48) for the patients and their mean infertility was 50.9 months (2 to 180). All the patients were included in three groups by the clinical variables in surgery: anastomosis number, anastomosis sites, epididymal fluid analysis. Bilateral and lateral anastomosis was in 50 and 23 cases, respectively. The anastomosis on caput, corpus and caudal was in 19, 46, and 8 cases respectively. Motile sperm in the epididymal fuild continuing flowage could be found in 55 patients. By contrast, immotile sperm could be found in 18 patients. Semen analysis was done at the end of 3 months, and patency was arbitrarily defined as >10 000 sperm/mL in ejaculate in at least one semen analysis after surgery.

RESULTS

Of all the patients, 53 were followed up. Sperm was present in the ejaculate in 38 patients postoperatively. The overall patency rate was 71.7% (38/53). Patency rates of bilateral surgery and of lateral surgery achieved 80.7% and 27.6%; of caput anastomosis 38.5%, of corpus anastomosis 78.8%, of caudal anastomosis 100%, of motile sperm with epididymal fluid continuing flowage 83.7% and of immotile sperm 40%, respectively. In the study, 17 patients (33.3%, 17/53) reported spontaneous pregnancy.

CONCLUSION

Except for microsurgical technology, bilateral anastomosis, corpus or caudal anastomosis, and motile sperm with epididymal fluid continuing flowage may improve patency rate postoperatively.

摘要

目的

评估影响显微外科输精管附睾吻合术通畅率的术中因素。

方法

2009年1月至2010年7月,73例梗阻性无精子症男性接受了纵向套叠式输精管附睾吻合术(LIVE)。患者的平均年龄(范围)为31岁(23至48岁),平均不孕时间为50.9个月(2至180个月)。根据手术中的临床变量将所有患者分为三组:吻合口数量、吻合部位、附睾液分析。双侧吻合50例,单侧吻合23例。吻合部位在附睾头、体、尾部分别为19例、46例和8例。55例患者的附睾液中有活动精子持续流出。相比之下,18例患者的精子不活动。术后3个月末进行精液分析,通畅被随意定义为术后至少一次精液分析中射精液中精子浓度>10000个/mL。

结果

所有患者中,53例进行了随访。术后38例患者的射精液中有精子。总体通畅率为71.7%(38/53)。双侧手术和单侧手术的通畅率分别为80.7%和27.6%;附睾头吻合的通畅率为38.5%,附睾体吻合的通畅率为78.8%,附睾尾吻合的通畅率为100%,附睾液中有活动精子持续流出的患者通畅率为83.7%,精子不活动的患者通畅率为40%。在该研究中,17例患者(33.3%,17/53)报告自然受孕。

结论

除显微外科技术外,双侧吻合、附睾体或附睾尾吻合以及附睾液中有活动精子持续流出可能会提高术后通畅率。

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