口腔黏膜微核细胞数量与癌变的相关性
[Correlation between the quantity of oral mucosal micronucleus cells and cancerization].
作者信息
Cao Jie, Liu Hong-wei, Liu Xiao-song, Jin Jian-qiu, Zhang Ping
机构信息
Department of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing 100034, China.
出版信息
Beijing Da Xue Xue Bao Yi Xue Ban. 2011 Aug 18;43(4):600-2.
OBJECTIVE
To explore the relationship between micronuclei and malignant development of oral epithelial dysplasia (OED).
METHODS
Oral exfoliated cells were smeared from 30 control subjects, 46 patients with oral lichen planus (OLP), 78 patients with oral leukoplakia (OLK) and hyperplasia, 30 patients with OLK and mild OED, 29 patients with OLK and moderate OED, 15 patients with OLK and severe OED and 22 patients with oral squamous cell carcinoma (OSCC).
RESULTS
Micronucleus rates declined according to the order of OSCC, OLK and severe OED, OLK and moderate OED, OLK and mild OED, OLK and hyperplasia, OLP and control groups (P<0.001).
CONCLUSION
Micronuclei may reflect the progression of oral epithelial malignant changes. It could be used in monitoring cancerization in following up cases regularly.
目的
探讨微核与口腔上皮异常增生（OED）恶变之间的关系。
方法
对30名对照受试者、46名口腔扁平苔藓（OLP）患者、78名口腔白斑（OLK）及增生患者、30名OLK合并轻度OED患者、29名OLK合并中度OED患者、15名OLK合并重度OED患者以及22名口腔鳞状细胞癌（OSCC）患者的口腔脱落细胞进行涂片。
结果
微核率按照OSCC组、OLK合并重度OED组、OLK合并中度OED组、OLK合并轻度OED组、OLK合并增生组、OLP组及对照组的顺序依次降低（P<0.001）。
结论
微核可能反映口腔上皮恶性变化的进程。可用于定期随访病例中癌变的监测。
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