He Xiaoye, Clarke Stephen J, McLachlan Andrew J
Department of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Curr Gerontol Geriatr Res. 2011;2011:628670. doi: 10.1155/2011/628670. Epub 2011 Aug 10.
Populations around the world are aging, and the associated increase in cancer incidence has led to the recognition of the importance of geriatric oncology. Chronological age is a poor determinant of pharmacological response to cancer chemotherapy agents. Age-associated changes in physiology and organ function have a significant impact on the clinical pharmacology of cancer chemotherapy agents used in cancer treatment. Altered response to medicines in older people is a consequence of changes in body composition, organ function, concomitant pathophysiology, multiple medications, genetic determinants of drug response, and patient's clinical status. These issues highlight the need to individualize the management of cancer in the older people with consideration of age-related changes in the clinical pharmacology of cancer drugs, analgesics, and adjunctive therapies.
世界各地的人口正在老龄化,癌症发病率的相应增加已使人们认识到老年肿瘤学的重要性。实足年龄并不是癌症化疗药物药理反应的良好决定因素。生理和器官功能的年龄相关变化对癌症治疗中使用的癌症化疗药物的临床药理学有重大影响。老年人对药物反应的改变是身体组成、器官功能、伴随的病理生理学、多种药物、药物反应的遗传决定因素以及患者临床状况变化的结果。这些问题凸显了在考虑癌症药物、镇痛药和辅助治疗临床药理学中与年龄相关变化的情况下,对老年癌症患者进行个体化管理的必要性。