Petridis Athanasios K, Doukas Alexandros, Mahvash Mehran, Dörner Lutz, Hugo Heinz Hermann, Mehdorn Hubertus Maximilian
University Hospital Kiel, Neurosurgery, Schittenhelmstrasse 10, Kiel, 24105, Germany.
BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.05.2009.1862. Epub 2009 Aug 19.
Meningiomas are tumours originating from the leptomeningeal covering of the brain and spinal cord and are generally benign and slow growing. Rarely, they show malignant anaplastic characteristics with a high recurrence rate. A number of factors have been reported to predict this high recurrence. Such factors are histopathological ones, such as necrosis and hypercellularity, the World Health Organization (WHO) grade, mitotic index, positivity of proliferation markers (Ki-67 or MIB-1), clinical parameters such as age, gender, localisation, cytogenetic factors and radiation treatment. The present case reports a patient with a giant meningioma over the right frontal lobe who had almost all possible negative prognostic parameters and showed an explosive multifocal recurrence in a timespan of about 5 months.
脑膜瘤是起源于脑和脊髓软脑膜被覆的肿瘤，通常为良性且生长缓慢。极少数情况下，它们会表现出恶性间变特征，复发率很高。据报道，有许多因素可预测这种高复发率。这些因素包括组织病理学因素，如坏死和细胞增多、世界卫生组织（WHO）分级、有丝分裂指数、增殖标志物（Ki-67或MIB-1）阳性，临床参数如年龄、性别、部位，细胞遗传学因素以及放射治疗。本病例报告了一名右额叶巨大脑膜瘤患者，该患者几乎具备所有可能的不良预后参数，并在约5个月的时间内出现了爆发性多灶性复发。
