Carter John D, Gérard Hervé C, Whittum-Hudson Judith A, Hudson Alan P
Department of Internal Medicine, Division of Rheumatology, University of South Florida, Tampa, FL, USA.
Int J Clin Rheumtol. 2011 Jun;6(3):333-345. doi: 10.2217/ijr.11.20.
The inflammatory arthritis that develops in some patients subsequent to urogenital infection by the obligate intracellular bacterial pathogen Chlamydia trachomatis, and that induced subsequent to pulmonary infection with C. pneumoniae, both have proved difficult to treat in either their acute or chronic forms. Over the last two decades, molecular genetic and other studies of these pathogens have provided a good deal of information regarding their metabolic and genetic structures, as well as the detailed means by which they interact with their host cells. In turn, these insights have provided for the first time a window into the bases for treatment failures for the inflammatory arthritis. In this article we discuss the biological bases for those treatment failures, provide suggestions as to research directions that should allow improvement in treatment modalities, and speculate on how treatment regimens that currently show promise might be significantly improved over the near future using nanotechological means.
一些患者在被专性细胞内细菌病原体沙眼衣原体泌尿生殖系统感染后发生的炎性关节炎，以及在被肺炎衣原体肺部感染后引发的炎性关节炎，无论是急性还是慢性形式，都已证明难以治疗。在过去二十年中，对这些病原体的分子遗传学和其他研究提供了大量有关其代谢和遗传结构的信息，以及它们与宿主细胞相互作用的详细方式。反过来，这些见解首次为炎性关节炎治疗失败的原因提供了一个窗口。在本文中，我们讨论了这些治疗失败的生物学基础，就应能改善治疗方式的研究方向提出建议，并推测目前显示出前景的治疗方案在不久的将来如何利用纳米技术手段得到显著改善。
