[肝纤维化和肝硬化——病因。第一部分]
[Liver fibrosis and cirrhosis--causes. Part I].
作者信息
Wirkowska Agnieszka, Paczek Leszek
机构信息
Klinika Immunologii Transplantologii i Chorób Wewnetrznych, Instytutu Transplantologii, Warszawskiego Uniwersytetu Medycznego.
出版信息
Przegl Lek. 2011;68(4):222-7.
Liver fibrosis is one of the most compound pathological process occurred as the answer to risen inflammation factor. It is characterized by balance disorders between syntesis and degradation ECM (Extracellular Matrix) by myofibroblasts. This appears when activated by inflammation factor HSC cells transform in myofibroblasts. Among major causes of the chronic liver inflammation, with parenchymal cells destruction and replace of connective tissue, are: hepatotropic viruses (HCV, HBV), alcohol, autoimmunologic disorders.
肝纤维化是对炎症因子升高所产生的最复杂的病理过程之一。其特征是成肌纤维细胞合成与降解细胞外基质（ECM）之间的平衡失调。当炎症因子激活肝星状细胞（HSC）转化为成肌纤维细胞时就会出现这种情况。慢性肝脏炎症的主要原因包括实质细胞破坏和结缔组织替代，这些原因有：嗜肝病毒（HCV、HBV）、酒精、自身免疫性疾病。
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