Children's Hospital Medical Center of Akron, Akron, Ohio, USA.
J Urol. 2011 Oct;186(4 Suppl):1576-80. doi: 10.1016/j.juro.2011.03.098. Epub 2011 Aug 19.
Sacral nerve modulation is a Food and Drug Administration approved treatment for refractory urgency, frequency, urge incontinence and nonobstructive urinary retention in adults. The sparse literature on sacral nerve modulation in children focuses on its initial efficacy in patients with neurogenic bladder and dysfunctional elimination. We describe our initial experience with sacral nerve modulation and the phenomenon of growth spurts associated with lead malfunction that necessitates revision.
After receiving institutional review board approval we retrospectively reviewed the charts of pediatric patients who underwent sacral nerve modulation surgery at our institution. Charts were examined for patient demographics, subjective success, the need for further surgery and success after revision.
Four patients underwent sacral nerve modulation at an average age of 12.1 years. All patients reported initial success, defined as greater than 50% symptom improvement. Subsequently 3 patients required a total of 5 revisions due to lead malfunction with an average of 1.5 years between surgeries. In those requiring revision the average somatic growth between revisions was 8.1 cm. Return of efficacy was reported after each revision. All patients had functioning nerve stimulators in place and continued to have a positive subjective response.
The sparse data on sacral nerve modulation in children shows efficacy and safety similar to those in adults. Somatic growth may be associated with lead malfunction and require surgical revision. We report a small series showing that revision can be done successfully and safely. Informed consent for sacral nerve modulation in pediatric patients should include a discussion of somatic growth as a possible cause of lead malfunction necessitating revision.
骶神经调节是食品和药物管理局批准的成人难治性尿急、尿频、急迫性尿失禁和非梗阻性尿潴留的治疗方法。关于儿童骶神经调节的文献很少,主要集中在其对神经源性膀胱和功能障碍性排尿的初始疗效上。我们描述了我们在儿童骶神经调节方面的初步经验,以及与导丝故障相关的生长突增现象,这需要进行修订。
在获得机构审查委员会批准后,我们回顾性地审查了在我们机构接受骶神经调节手术的儿科患者的病历。检查了患者的人口统计学资料、主观疗效、是否需要进一步手术以及修订后的疗效。
4 名患者在平均年龄为 12.1 岁时接受了骶神经调节。所有患者均报告了初始成功,定义为症状改善超过 50%。随后,3 名患者因导丝故障共进行了 5 次手术,平均手术间隔 1.5 年。在需要修订的患者中,每次修订之间的平均躯体生长为 8.1cm。每次修订后都报告了疗效的恢复。所有患者的神经刺激器均正常工作,继续有积极的主观反应。
关于儿童骶神经调节的稀疏数据表明,其疗效和安全性与成人相似。躯体生长可能与导丝故障有关,需要手术修正。我们报告了一个小系列病例,表明可以成功和安全地进行修正。骶神经调节在儿科患者中的知情同意应包括讨论躯体生长作为导致导丝故障需要修正的可能原因。