Department of Pharmacology & Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, Chandigarh, India.
Pharmacol Rep. 2011;63(3):618-28. doi: 10.1016/s1734-1140(11)70574-6.
A cerebrovascular accident, or stroke, is defined as the abrupt onset of a neurological deficit, which can be due to ischemia. Cerebral ischemia is caused by a reduction in blood flow that thereby decreases cerebral metabolism. Chronic cerebral hypoperfusion leads to irreversible brain damage and plays an important role in the development of certain types of dementia. Vinpocetine, chemically known as ethyl apovincaminate, is a vinca alkaloid that exhibits cerebral blood-flow enhancing and neuroprotective effects. Non-clinical and clinical studies have suggested multiple mechanisms responsible for the beneficial neuroprotective effects of vinpocetine. As no significant side effects related to vinpocetine treatment have been reported, it is considered to be safe for long-term use. This vasoactive alkaloid is widely marketed as a supplement for vasodilation and as a nootropic for the improvement of memory. The present review focuses on studies investigating the role of vinpocetine in cerebrovascular diseases.
脑血管意外，又称中风，是指突发性神经功能缺损，其可能由缺血引起。脑缺血是由于血流减少，从而降低脑代谢所致。慢性脑灌注不足导致不可逆转的脑损伤，并在某些类型痴呆的发展中起重要作用。长春西汀，化学上称为乙基丙烯酰胺，是一种长春碱生物碱，具有增加脑血流和神经保护作用。非临床和临床研究表明，长春西汀具有多种有益的神经保护作用机制。由于没有报道与长春西汀治疗相关的明显副作用，因此认为它可长期安全使用。这种血管活性生物碱被广泛用作血管扩张剂和作为改善记忆的益智药的补充剂。本综述重点介绍了研究长春西汀在脑血管疾病中的作用的研究。
