From the Divisions of Pediatric and Adolescent Gynecology and Epidemiology, Mayo Clinic, Rochester, Minnesota; the Department of Gynaecology, Royal Children's Hospital, Melbourne, Australia; and the Department of Pathology, Mayo Clinic Health System, Austin, Texas.
Obstet Gynecol. 2011 Sep;118(3):529-536. doi: 10.1097/AOG.0b013e31822a69db.
To estimate the incidence of breast carcinoma and survival in patients younger than 25 years old, and to describe presenting clinical signs and symptoms of breast cancer in this age group.
A population-based descriptive study and case review in Olmsted County, Minnesota, was conducted using the resources of the Rochester Epidemiology Project. Participants were Olmsted County girls and women younger than 25 years old with histopathologically confirmed breast carcinoma diagnosed between 1935 and 2005. Nonresidents who presented to a medical facility within Olmsted County during this time period were included in some portions of the analysis. Main outcome measures were age-adjusted incidence, 5-year survival, and clinical presentation of breast carcinoma in girls and women younger than 25 years of age.
With four breast carcinomas observed in Olmsted County residents over 1,201,539 person-years, the annual age-adjusted incidence of breast cancer in this population was 3.2 per million (95% confidence interval, 0.1-6.2). All four cancers occurred in the 20- to 24-year age group (age-specific incidence, 16.2 per million). Eight additional cases of breast carcinoma were identified in nonresidents. Delay in diagnosis was common. All had at least one feature worrisome for an aggressive neoplasm identified in their clinical history, on physical examination or by imaging.
Breast carcinoma in young women is very rare, associated with delayed diagnosis, and usually associated with concerning features requiring biopsy.
III.
评估 25 岁以下患者乳腺癌的发病率和生存率，并描述该年龄段乳腺癌的临床表现。
在明尼苏达州奥姆斯特德县进行了一项基于人群的描述性研究和病例回顾，利用罗切斯特流行病学项目的资源。研究对象为奥姆斯特德县 25 岁以下经组织病理学证实的乳腺癌患者。在这段时间内，在奥姆斯特德县的医疗设施就诊的非居民也被纳入了部分分析。主要观察指标为年龄调整后的发病率、5 年生存率以及 25 岁以下女孩和妇女乳腺癌的临床表现。
在奥姆斯特德县居民的 1201539 人年中观察到 4 例乳腺癌，该人群的乳腺癌年发病率为 3.2/百万（95%置信区间，0.1-6.2）。所有癌症均发生在 20-24 岁年龄组（年龄特异性发病率为 16.2/百万）。还在非居民中发现了另外 8 例乳腺癌病例。诊断延迟很常见。在他们的临床病史、体格检查或影像学检查中，所有患者至少有一个特征提示为侵袭性肿瘤。
年轻女性的乳腺癌非常罕见，与诊断延迟有关，通常与需要活检的令人担忧的特征有关。
III。
