Kawamoto Shuji, Tatsumi Kenichiro, Kataoka Tomomi, Kamikawa Tatsuo, Yanagida Toyonobu, Mandai Ryoichi
Department of Anesthesiology, Nagahama City Hospital, Nagahama 526-8580.
Masui. 2011 Aug;60(8):892-6.
It has become a popular practice to add opioids to spinal solutions to enhance and prolong intraoperative and postoperative analgesia in cesarean section. Morphine is the opioid most widely used for this purpose, but there are few reports about intrathecal buprenorphine. We evaluated the postoperative analgesic effect of intrathecal buprenorphine compared with intrathecal morphine after cesarean section.
We retrospectively compared group B (n = 20) receiving tetracaine 10mg plus intrathecal buprenorphine 0.05 mg with group M (n = 24) receiving tetracaine 10 mg with intrathecal morphine 0.1 mg in elective cesarean section under spinal anesthesia.
There were no significant differences between the groups in time to first postoperative supplemental analgesics, times of using postoperative supplemental analgesics and antiemetics within 24 hours after operation, and the incidence of postoperative nausea and vomiting and pruritus.
It is concluded that intrathecal buprenorphine 0.05 mg provides similar postoperative analgesic effect with intrathecal morphine 0.1 mg without any increases of side-effects in cesarean section.
在剖宫产手术中,向脊髓溶液中添加阿片类药物以增强和延长术中和术后镇痛已成为一种普遍做法。吗啡是最广泛用于此目的的阿片类药物,但关于鞘内注射丁丙诺啡的报道较少。我们评估了剖宫产术后鞘内注射丁丙诺啡与鞘内注射吗啡的术后镇痛效果。
我们回顾性比较了在脊髓麻醉下进行择期剖宫产手术的B组(n = 20),其接受10mg丁卡因加0.05mg鞘内注射丁丙诺啡,与M组(n = 24),其接受10mg丁卡因加0.1mg鞘内注射吗啡。
两组在术后首次补充镇痛药的时间、术后24小时内使用术后补充镇痛药和止吐药的次数以及术后恶心、呕吐和瘙痒的发生率方面无显著差异。
得出的结论是,0.05mg鞘内注射丁丙诺啡在剖宫产中提供了与0.1mg鞘内注射吗啡相似的术后镇痛效果,且未增加任何副作用。