蛋白酶体调节剂 9 与腕管综合征。

Proteasome modulator 9 and carpal tunnel syndrome.

机构信息

Laboratory of Molecular Genetics of Complex and Monogenic Disorders, Department of Medicine and Cellular & Molecular Physiology and Biostatistics, Penn State University and MS Hershey Medical Center, Hershey, PA 17033, United States.

出版信息

Diabetes Res Clin Pract. 2011 Nov;94(2):e47-9. doi: 10.1016/j.diabres.2011.07.040. Epub 2011 Sep 8.

DOI:10.1016/j.diabres.2011.07.040

PMID:21862167

Abstract

Proteasome modulator 9 (PSMD9) is linked to type 2 diabetes (T2D). The author studied whether PSMD9 IVS3 + nt460 A > G, IVS3 + nt437 T > C and E197 are linked to carpal tunnel syndrome in T2D Italian families. Non-parametric linkage, linkage disequilibrium-based and independent SNPs-based linkage analyses were performed. The PSMD9 SNPs show linkage to carpal tunnel syndrome.

摘要

蛋白酶体调节剂 9 (PSMD9) 与 2 型糖尿病 (T2D) 有关。作者研究了 PSMD9 IVS3 + nt460 A > G、IVS3 + nt437 T > C 和 E197 是否与意大利 2 型糖尿病家族的腕管综合征有关。进行了非参数连锁、连锁不平衡和独立 SNP 连锁分析。PSMD9 SNP 与腕管综合征有连锁关系。