Shi Meimei, Wu Xiaobo, Wei Chunling, Yang Minghao, Liu Zhiqiang, Ren Wei
College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi, P.R. China.
Neuroreport. 2011 Oct 26;22(15):762-6. doi: 10.1097/WNR.0b013e32834ae32e.
The N-methyl-D-aspartate receptors (NMDARs) play a key role in synaptic plasticity, but it remains unclear whether the intrinsic-firing properties, another major determinant of the functional output of neurons, are regulated by activation of NMDARs. Here, we examine the effects of NMDAR activation on the intrinsic-firing properties of medium spiny neurons in nucleus accumbens in vitro. NMDAR activation by bath application of NMDA increased both the intrinsic excitability and the spike adaptation of these neurons. Furthermore, selective activation of NR2A-containing NMDARs mediated the enhancement of spike adaptation, whereas selective activation of NR2B-containing NMDARs increased the intrinsic excitability, suggesting that NR2A-containing and NR2B-containing NMDARs play different roles in mediating the intrinsic-firing properties of neurons.
N-甲基-D-天冬氨酸受体（NMDARs）在突触可塑性中起关键作用，但尚不清楚神经元功能输出的另一个主要决定因素——固有放电特性是否受NMDARs激活的调节。在此，我们研究了NMDAR激活对体外伏隔核中中等棘状神经元固有放电特性的影响。通过浴槽应用NMDA激活NMDARs，增加了这些神经元的固有兴奋性和动作电位适应。此外，含NR2A的NMDARs的选择性激活介导了动作电位适应的增强，而含NR2B的NMDARs的选择性激活增加了固有兴奋性，这表明含NR2A和含NR2B的NMDARs在介导神经元固有放电特性中发挥不同作用。
