Qamra Suneel, Roy Jyotirmoy, Srivastava Praval
Regional Medical Research Centre for Tribals, Jabalpur-482 003, Madhya Pradesh, India.
Ann Hum Biol. 2011 Nov;38(6):685-90. doi: 10.3109/03014460.2011.608378. Epub 2011 Aug 24.
Reliable reports on growth impairment in sickle cell trait (SCT) children in India are lacking despite contradictory findings reported earlier.
The present study assessed the impact of SCT on physical growth of tribal children of Mandla district.
Weight, height, circumferences, breadths, lengths and skinfolds were recorded on 6190 children, inclusive of 732 SCT children, from birth to 12 years of age using a cross-sectional design. The sickle test was conducted in the field using 2% sodium metabisulphite followed by electrophoresis.
No significant difference in mean values was observed in the majority of the age groups between SCT and normal children for all 11 body measurements. However, inconsistent growth patterns in these measurements among SCT children were evident. Body weight was more deficient than height or other body measurements in the children when compared to Indian and National Centre for Health Statistics (NCHS) standards, while bicristal breadth was comparable with Indian standards.
There was no significant impact of SCT observed on growth of children irrespective of sex. Notably, growth of SCT girls was comparable to their normal counterparts. The actual growth difference between normal and SCT children may have been masked on account of poor attainment of annual gain in each successive age group.
尽管早期有相互矛盾的研究结果报道，但印度关于镰状细胞性状（SCT）儿童生长发育受损的可靠报告仍然缺乏。
本研究评估了SCT对曼德拉地区部落儿童身体生长的影响。
采用横断面设计，记录了6190名儿童从出生到12岁的体重、身高、周长、宽度、长度和皮褶厚度，其中包括732名SCT儿童。现场使用2%的焦亚硫酸钠进行镰状试验，随后进行电泳。
在所有11项身体测量中，大多数年龄组的SCT儿童和正常儿童之间的平均值没有显著差异。然而，SCT儿童在这些测量中的生长模式不一致是明显的。与印度和国家卫生统计中心（NCHS）的标准相比，这些儿童的体重比身高或其他身体测量指标更不足，而双髋间宽度与印度标准相当。
无论性别如何，均未观察到SCT对儿童生长有显著影响。值得注意的是，SCT女孩的生长情况与正常女孩相当。由于每个连续年龄组的年生长增量未达到标准，正常儿童和SCT儿童之间实际的生长差异可能被掩盖了。
