Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women's Medical University, Owada-shinden, Yachiyo, Chiba, Japan.
Retina. 2012 Jan;32(1):86-91. doi: 10.1097/IAE.0b013e31821801de.
To investigate whether vascular endothelial growth factor, soluble intercellular adhesion molecule-1 (sICAM-1), and pigment epithelium-derived factor are associated with serous retinal detachment (SRD) secondary to branch retinal vein occlusion.
The subjects were 44 branch retinal vein occlusion patients with macular edema and 16 controls. Patients were divided into 2 groups by optical coherence tomography findings, that is, 18 patients with SRD and 26 with cystoid macular edema. The area of capillary nonperfusion was measured with fluorescein angiography and Scion Image software. Vitreous fluid samples obtained during pars plana vitrectomy were examined by enzyme-linked immunosorbent assay.
The incidence of major branch retinal vein occlusion was significantly higher in SRD patients (17/18, 94%) than in cystoid macular edema patients (15/26, 58%, P = 0.007), while the nonperfused retinal area was significantly larger in SRD patients (P = 0.006). Vitreous fluid levels of vascular endothelial growth factor and soluble intercellular adhesion molecule-1 (sICAM-1) showed a significant increase across the 3 groups (control group, cystoid macular edema group, and SRD group) (P trend < 0.001 and P trend < 0.001, respectively), while the pigment epithelium-derived factor level showed a significant decrease across the 3 groups (P trend < 0.001).
An excessive increase of vascular permeability secondary to upregulation of vascular endothelial growth factor and soluble intercellular adhesion molecule-1 (sICAM-1) along with downregulation of pigment epithelium-derived factor may contribute to the development of SRD in BRVO patients.
研究血管内皮生长因子、可溶性细胞间黏附分子-1（sICAM-1）和色素上皮衍生因子是否与分支静脉阻塞继发的浆液性视网膜脱离（SRD）有关。
本研究纳入了 44 例伴有黄斑水肿的分支静脉阻塞患者和 16 名对照者。根据光学相干断层扫描检查结果将患者分为 2 组，即 18 例 SRD 患者和 26 例囊样水肿患者。用荧光素血管造影和 Scion Image 软件测量无灌注毛细血管面积。通过酶联免疫吸附试验检测接受玻璃体切割术时获得的玻璃体液样本。
SRD 患者（17/18，94%）大分支静脉阻塞的发生率明显高于囊样水肿患者（15/26，58%，P=0.007），而 SRD 患者无灌注视网膜面积明显更大（P=0.006）。血管内皮生长因子和可溶性细胞间黏附分子-1（sICAM-1）的玻璃体液水平在 3 组（对照组、囊样水肿组和 SRD 组）中均显著升高（P 趋势<0.001 和 P 趋势<0.001），而色素上皮衍生因子水平在 3 组中均显著降低（P 趋势<0.001）。
血管内皮生长因子和可溶性细胞间黏附分子-1（sICAM-1）上调以及色素上皮衍生因子下调导致的血管通透性过度增加可能导致 BRVO 患者发生 SRD。
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