静脉注射氨甲环酸对剖宫产术中及术后出血量的影响。
Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery.
机构信息
Anesthesia and Analgesia Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Int J Gynaecol Obstet. 2011 Dec;115(3):224-6. doi: 10.1016/j.ijgo.2011.07.015. Epub 2011 Aug 27.
OBJECTIVE
To assess the effect of intravenous tranexamic acid on blood loss during and after cesarean delivery.
METHODS
One hundred pregnant women were randomized to receive either 10 mg/kg of tranexamic acid or placebo intravenously 20 minutes before incision in a double-blind controlled study. Postplacental delivery blood loss, postoperative hemorrhage 2 hours after surgery, and oxytocin administration were recorded.
RESULTS
The patients' mean age, weight, and duration of surgery were similar between the 2 groups. Mean blood loss was significantly less in the tranexamic acid group compared with the control group for both intraoperative bleeding (262.5 ± 39.6 vs 404.7 ± 94.4 mL) and postoperative bleeding (67.1 ± 6.5 vs 141.0 ± 33.9 mL; P<0.001), respectively. Oxytocin administration was significantly less in the tranexamic acid group compared with the control group (39 ± 5.8 vs 43 ± 5.4 units; P=0.001).
CONCLUSION
Intravenous tranexamic acid decreased intra- and postoperative blood loss and oxytocin administered in patients delivered by cesarean.
目的
评估剖宫产术中及术后静脉使用氨甲环酸对出血量的影响。
方法
采用双盲对照研究，将 100 例孕妇随机分为两组，分别在切开前 20 分钟静脉给予 10 mg/kg 氨甲环酸或安慰剂。记录胎盘娩出后出血量、术后 2 小时手术出血及催产素使用情况。
结果
两组患者的平均年龄、体重和手术时间相似。与对照组相比，氨甲环酸组术中出血量（262.5±39.6 比 404.7±94.4 mL）和术后出血量（67.1±6.5 比 141.0±33.9 mL）均明显减少（均 P<0.001）。与对照组相比，氨甲环酸组催产素使用量明显减少（39±5.8 比 43±5.4 单位；P=0.001）。
结论
静脉使用氨甲环酸可减少剖宫产术中及术后的出血量，并减少催产素的使用。
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