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[杏仁核功能神经内分泌调节系统中的性类固醇与单胺类物质]

[Sex steroids and monoamines in the system of neuroendocrine regulation of amygdala functions].

作者信息

Akhmadeev A V, Kalimullina L B

出版信息

Ross Fiziol Zh Im I M Sechenova. 2011 May;97(5):483-91.

Abstract

The aim of this review is a review of literature data, which characterize participation of monoamines brain systems and sex steroids in regulation (modulation) of the amygdalas' functions. Shown were characteristic noradrenergic, dopaminergic and serotoninergic systems and their representation in amygdala. Effect ofnoradrenaline, dopamine and serotonine on neurons of Amygdala was shown realized from appropriate cell receptors under modulated influence of sex steroids. Combined participation of monoamines and sex steroids occur in regulation of activity in cyclic centre of secretion and releasing of gonadotropins, constituted a base of forming adaptive (sexual, food and aggressive-defensive) behaviour, including stress reaction. The presented data could be used for understanding influence of gender factor on personality characteristics of humans, cognitive abilities and behavioural reactions, and also in application to development of optimal medicinal treatment of psychoneurological diseases.

摘要

本综述的目的是回顾文献数据,这些数据描述了单胺能脑系统和性类固醇在杏仁核功能调节(调制)中的参与情况。展示了特征性的去甲肾上腺素能、多巴胺能和5-羟色胺能系统及其在杏仁核中的表现。去甲肾上腺素、多巴胺和5-羟色胺对杏仁核神经元的作用表明是在性类固醇的调节影响下通过相应的细胞受体实现的。单胺和性类固醇共同参与促性腺激素分泌和释放的周期性中心的活动调节,构成了形成适应性(性、食物和攻击防御)行为(包括应激反应)的基础。所呈现的数据可用于理解性别因素对人类人格特征、认知能力和行为反应的影响,也可应用于精神神经疾病最佳药物治疗的开发。

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