MitoBamAnnotator：一种用于检测和注释人类线粒体 DNA 序列异质性的基于网络的工具。

MitoBamAnnotator: A web-based tool for detecting and annotating heteroplasmy in human mitochondrial DNA sequences.

机构信息

National Institute for Biotechonology in the Negev, Beer Sheva, Israel.

出版信息

Mitochondrion. 2011 Nov;11(6):924-8. doi: 10.1016/j.mito.2011.08.005. Epub 2011 Aug 22.

DOI:10.1016/j.mito.2011.08.005

Abstract

The use of Next-Generation Sequencing of mitochondrial DNA is becoming widespread in biological and clinical research. This, in turn, creates a need for a convenient tool that detects and analyzes heteroplasmy. Here we present MitoBamAnnotator, a user friendly web-based tool that allows maximum flexibility and control in heteroplasmy research. MitoBamAnnotator provides the user with a comprehensively annotated overview of mitochondrial genetic variation, allowing for an in-depth analysis with no prior knowledge in programming.

摘要

线粒体 DNA 的下一代测序技术在生物和临床研究中得到了广泛应用。这反过来又产生了对检测和分析异质性的便捷工具的需求。在这里，我们介绍了 MitoBamAnnotator，这是一种用户友好的基于网络的工具，允许在异质性研究中最大程度地灵活和控制。MitoBamAnnotator 为用户提供了线粒体遗传变异的全面注释概述，允许在没有编程知识的情况下进行深入分析。