University of California, Davis Health System Eye Center, Sacramento, CA 95817, USA.
J Glaucoma. 2012 Oct-Nov;21(8):523-9. doi: 10.1097/IJG.0b013e318227a565.
To determine the effect of conjunctival incision location on the long-term efficacy of nonvalved glaucoma drainage devices.
We conducted a retrospective review of patients ≥18 years of age with uncontrolled glaucoma [intraocular pressure (IOP) ≥18 mm Hg] who underwent glaucoma drainage device implantation. A comparison was made of a limbal-based (LB-BGI) versus fornix-based (FB-BGI) conjunctival flap during placement of a 350-mm Baerveldt glaucoma implant (AMO, Santa Ana, CA) in subjects with at least 1 year of follow-up data. The primary outcome measure was IOP; secondary outcome measures were medication burden, visual acuity, and surgical complications.
One hundred sixty eyes of 147 glaucoma patients were included. Two years after surgery, the IOP in the LB-BGI group was 14.3±5.3 mm Hg and in the FB-BGI group 13.1±4.7 mm Hg (P=0.47). Overall success of IOP control was achieved at the final visit (range 1 to 5 y) in 90% of the LB-BGI group and 87% of the FB-BGI group (P=0.63). The medication burden of the 2 groups at 1 and 2 years after surgery was not statistically significantly different. Worsening of visual acuity by more than 2 lines was not statistically different between the groups 2 years after the surgery and at the final visit (P=0.47, P=0.60, respectively). A greater number of eyes developed endophthalmitis and were more likely to undergo subsequent tube revision in the FB-BGI group, but the differences were not significant.
Both incision techniques were equally effective in controlling IOP. Each surgical approach has its advantages and this study suggests that either technique may be used safely and effectively.
确定结膜切口位置对非阀式青光眼引流装置长期疗效的影响。
我们对 18 岁以上患有未控制青光眼(眼压[IOP]≥18mmHg)并接受青光眼引流装置植入术的患者进行了回顾性研究。对 350mm Baerveldt 青光眼植入物(AMO,Santa Ana,CA)放置时基于缘(LB-BGI)与基于穹窿(FB-BGI)结膜瓣的比较,在至少有 1 年随访数据的患者中进行。主要观察指标为眼压;次要观察指标为药物负担、视力和手术并发症。
147 例青光眼患者的 160 只眼被纳入研究。术后 2 年,LB-BGI 组的 IOP 为 14.3±5.3mmHg,FB-BGI 组为 13.1±4.7mmHg(P=0.47)。在最终随访(1 至 5 年)时,LB-BGI 组 90%和 FB-BGI 组 87%的患者达到了 IOP 控制的总体成功(P=0.63)。术后 1 年和 2 年,两组的药物负担无统计学差异。术后 2 年和最终随访时,两组视力下降超过 2 行的比例无统计学差异(P=0.47,P=0.60)。FB-BGI 组有更多的眼发生眼内炎,并且更有可能进行后续的管修订,但差异无统计学意义。
两种切口技术在控制眼压方面同样有效。每种手术方法都有其优点,本研究表明,任何一种技术都可以安全有效地使用。