Oyama Genko, Foote Kelly D, Iyer Sanjay S, Zeilman Pamela, Hwynn Nelson, Jacobson Charles E, Malaty Irene A, Fernandez Hubert H, Rodriguez Ramon L, Okun Michael S
Department of Neurology, University of Florida Movement Disorders Center, Gainesville, FL 32610, USA.
Neurologist. 2011 Sep;17(5):282-5. doi: 10.1097/NRL.0b013e318217367b.
Respiratory dyskinesia is a rare but disabling complication of levodopa therapy for Parkinson disease; however, its treatment has been limited to medication optimization.
A 72-year-old woman with a 6-year history of Parkinson disease presented with severe and debilitating levodopa-induced respiratory dyskinesia, which manifested with a short and shallow breathing pattern and panting. These symptoms were observed coincident with limb and truncal dyskinesias. Both respiratory and limb/trunk dyskinesias were addressed by the implantation of a unilateral globus pallidus interna deep brain stimulator (GPi-DBS).
Although the mechanism of involvement of the respiratory system in dyskinesia is unknown, GPi-DBS seems to be a potentially viable treatment option for these patients.
呼吸运动障碍是帕金森病左旋多巴治疗中一种罕见但致残的并发症；然而，其治疗一直局限于药物优化。
一名患有6年帕金森病病史的72岁女性出现严重且致残的左旋多巴诱导的呼吸运动障碍，表现为呼吸模式短浅及气喘。这些症状与肢体和躯干运动障碍同时出现。通过植入单侧内侧苍白球脑深部电刺激器（GPi-DBS）解决了呼吸及肢体/躯干运动障碍问题。
尽管运动障碍中呼吸系统受累的机制尚不清楚，但GPi-DBS似乎是这些患者潜在可行的治疗选择。
