单侧苍白球腹后部脑深部电刺激术治疗帕金森病左旋多巴诱导的呼吸运动障碍
Unilateral GPi-DBS as a treatment for levodopa-induced respiratory dyskinesia in Parkinson disease.
作者信息
Oyama Genko, Foote Kelly D, Iyer Sanjay S, Zeilman Pamela, Hwynn Nelson, Jacobson Charles E, Malaty Irene A, Fernandez Hubert H, Rodriguez Ramon L, Okun Michael S
机构信息
Department of Neurology, University of Florida Movement Disorders Center, Gainesville, FL 32610, USA.
出版信息
Neurologist. 2011 Sep;17(5):282-5. doi: 10.1097/NRL.0b013e318217367b.
BACKGROUND
Respiratory dyskinesia is a rare but disabling complication of levodopa therapy for Parkinson disease; however, its treatment has been limited to medication optimization.
CASE REPORT
A 72-year-old woman with a 6-year history of Parkinson disease presented with severe and debilitating levodopa-induced respiratory dyskinesia, which manifested with a short and shallow breathing pattern and panting. These symptoms were observed coincident with limb and truncal dyskinesias. Both respiratory and limb/trunk dyskinesias were addressed by the implantation of a unilateral globus pallidus interna deep brain stimulator (GPi-DBS).
CONCLUSIONS
Although the mechanism of involvement of the respiratory system in dyskinesia is unknown, GPi-DBS seems to be a potentially viable treatment option for these patients.
背景
呼吸运动障碍是帕金森病左旋多巴治疗中一种罕见但致残的并发症；然而，其治疗一直局限于药物优化。
病例报告
一名患有6年帕金森病病史的72岁女性出现严重且致残的左旋多巴诱导的呼吸运动障碍，表现为呼吸模式短浅及气喘。这些症状与肢体和躯干运动障碍同时出现。通过植入单侧内侧苍白球脑深部电刺激器（GPi-DBS）解决了呼吸及肢体/躯干运动障碍问题。
结论
尽管运动障碍中呼吸系统受累的机制尚不清楚，但GPi-DBS似乎是这些患者潜在可行的治疗选择。
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