Departamento de Genética, Evolução e Bioagentes, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brasil.
Mem Inst Oswaldo Cruz. 2011 Aug;106 Suppl 1:79-84. doi: 10.1590/s0074-02762011000900010.
It is generally accepted that Plasmodium vivax, the most widely distributed human malaria parasite, causes mild disease and that this species does not sequester in the deep capillaries of internal organs. Recent evidence, however, has demonstrated that there is severe disease, sometimes resulting in death, exclusively associated with P. vivax and that P. vivax-infected reticulocytes are able to cytoadhere in vitro to different endothelial cells and placental cryosections. Here, we review the scarce and preliminary data on cytoadherence in P. vivax, reinforcing the importance of this phenomenon in this species and highlighting the avenues that it opens for our understanding of the pathology of this neglected human malaria parasite.
人们普遍认为，分布最广泛的人类疟原虫——间日疟原虫（Plasmodium vivax）引起的疾病较轻，而且该物种不会在内部器官的深部毛细血管中隔离。然而，最近的证据表明，有一种严重的疾病，有时甚至会导致死亡，这种疾病只与间日疟原虫有关，而且感染间日疟原虫的网织红细胞能够在体外与不同的内皮细胞和胎盘冷冻切片发生细胞黏附。在这里，我们回顾了间日疟原虫细胞黏附的有限且初步的数据，强调了这种现象在该物种中的重要性，并突出了它为我们理解这种被忽视的人类疟原虫病理学开辟的途径。
