Division of Urology, Department of Surgery, University of Tennessee, Graduate School of Medicine, Knoxville, TN 37920, USA.
Urology. 2011 Sep;78(3):496-9. doi: 10.1016/j.urology.2011.06.010.
Because of many societal factors, the number of men over the age of 35 desiring to conceive children has increased over the past 40 years. The purpose of this review is to identify the mechanisms of aging on male fertility, to evaluate the genetic risk for the offspring, and to provide counseling for the older male. Most evidence suggests trends that increased paternal age has negative effects on fertility and some genetic risk for offspring, but the age at which the risk develops and the magnitude of risk are poorly defined.
由于许多社会因素的影响，过去 40 年来，希望生育孩子的 35 岁以上男性人数有所增加。本文旨在探讨男性生育能力随年龄变化的机制，评估后代的遗传风险，并为高龄男性提供咨询服务。大多数证据表明，父亲年龄增加对生育能力和后代遗传风险有负面影响，但风险发生的年龄和风险程度尚未明确界定。
