Gaboury Isabelle, Coyle Kathryn, Coyle Douglas, Le Saux Nicole
Children's Hospital of Eastern Ontario Research Institute;
Paediatr Child Health. 2010 Sep;15(7):e14-8. doi: 10.1093/pch/15.7.e14.
In Canada, antimicrobial treatment is the most common approach for acute otitis media. The aim of the present study was to compare the cost effectiveness of treatment with amoxicillin versus a watch-and-wait approach (WAIT) within a Canadian pediatric setting. Four hundred eighty-eight children, six months to five years of age, who participated in a randomized controlled trial were included in the study. The average medication costs per patient were higher for the amoxicillin group ($17.26) than for the WAIT group ($4.33). However, both health care ($148.44 versus $162.48) and patient costs ($23.50 versus $31.87) were greater for the WAIT group. The mean cost of treatment for the amoxicillin group was $189.20, compared with $198.68 for the WAIT group. Amoxicillin may be cost effective in treating children with acute otitis media. The potential development of antimicrobial resistance was not addressed in the present study.
在加拿大，抗菌治疗是急性中耳炎最常见的治疗方法。本研究的目的是比较在加拿大儿科环境中，阿莫西林治疗与观察等待方法（WAIT）的成本效益。参与一项随机对照试验的488名6个月至5岁的儿童被纳入该研究。阿莫西林组每位患者的平均药物成本（17.26美元）高于观察等待组（4.33美元）。然而，观察等待组的医疗保健成本（148.44美元对162.48美元）和患者成本（23.50美元对31.87美元）都更高。阿莫西林组的平均治疗成本为189.20美元，而观察等待组为198.68美元。阿莫西林在治疗急性中耳炎儿童方面可能具有成本效益。本研究未涉及抗菌药物耐药性的潜在发展。
