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直肠癌治疗的变化:低位前切除术的应用增加。

Changes in treatment of rectal cancer: increased use of low anterior resection.

机构信息

1st Propedeutic Surgical Clinic, Aristotle University of Thessaloniki, AHEPA General Hospital, St Kyriakidi 1, TK 54636 Thessaloniki, Greece.

出版信息

Tech Coloproctol. 2011 Oct;15 Suppl 1:S51-4. doi: 10.1007/s10151-011-0731-3.

Abstract

PURPOSE

The most common surgical procedures for patients with rectal cancer are low anterior resection (LAR) or abdominoperineal excision (APE). The aim of the present study is to evaluate and report the changes in the incidence of LAR and APE in the surgical treatment of rectal cancer over the last 15 years in a single surgical department.

METHODS

The patient sample consisted of 251 consecutive patients (mean age 65.17; age range 22-87) that underwent surgical treatment for rectal cancer in a single center from 1996 to 2010. This time frame was divided into three 5-year periods (1996-2000, 2001-2005 and 2006-2010). Patients were classified into one of the aforementioned groups, depending on the date of their treatment.

RESULTS

In the first period (1996-2000), 71 patients were treated for rectal cancer. Among them, 32.4% (n = 23) underwent an abdominoperineal excision (APE) while 56.3% (n = 40) were treated with LAR. In the second period (2001-2005), included 102 patients, from which 29.4% (n = 30) received an APE and 60.8% (n = 62) underwent a LAR for their disease. In the final period (2006-2010), from the 78 patients, only 12.8% (n = 10) of them underwent APE, while 74.3% (n = 58) were treated with LAR. There was a statistically significant (chi-square test, P = 0.005) difference between the 3 periods of time concerning the performance of LAR and APE.

CONCLUSIONS

According to the results of the present study, the rates of APE seem to decrease during the last 15 years, while LAR is more widely used in the surgical treatment of rectal cancer.

摘要

目的

对于直肠癌患者,最常见的手术方法是低位前切除术(LAR)或腹会阴切除术(APE)。本研究旨在评估和报告在过去 15 年中,在一个单一的外科部门,直肠癌手术治疗中 LAR 和 APE 发生率的变化。

方法

患者样本包括 251 例连续患者(平均年龄 65.17 岁;年龄范围 22-87 岁),这些患者于 1996 年至 2010 年在一个单一中心接受直肠癌手术治疗。这一时间框架分为三个 5 年期间(1996-2000 年、2001-2005 年和 2006-2010 年)。根据治疗日期,将患者分为上述组之一。

结果

在第一个时期(1996-2000 年),有 71 例直肠癌患者接受治疗。其中,32.4%(n=23)接受腹会阴切除术(APE),56.3%(n=40)接受 LAR。在第二个时期(2001-2005 年),有 102 例患者,其中 29.4%(n=30)接受 APE,60.8%(n=62)接受 LAR。在最后一个时期(2006-2010 年),78 例患者中,仅 12.8%(n=10)接受 APE,74.3%(n=58)接受 LAR。LAR 和 APE 的执行情况在 3 个时间段之间存在统计学显著差异(卡方检验,P=0.005)。

结论

根据本研究结果,在过去 15 年中,APE 的比率似乎有所下降,而 LAR 在直肠癌的手术治疗中得到更广泛的应用。

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