一名甲状腺功能亢进患者出现体重减轻和严重黄疸。
Weight loss and severe jaundice in a patient with hyperthyroidism.
作者信息
Breidert M, Offensperger S, Blum H E, Fischer R
机构信息
Department of Internal Medicine I, District Hospital Clinic Altmühltal, Kösching, Germany.
出版信息
Z Gastroenterol. 2011 Sep;49(9):1267-9. doi: 10.1055/s-0029-1246059. Epub 2011 Sep 1.
BACKGROUND
Thyrotoxicosis may significantly alter hepatic function and is associated with autoimmune disorders of the liver.
CASE REPORT
We report the case of a thyrotoxic patient with Graves' disease and histologically established cholestatic hepatitis. Medical treatment of hyperthyroidism normalized liver function tests.
CONCLUSIONS
In patients with elevated liver function parameters and jaundice of unknown origin, thyroid function should generally be tested. Moreover, medical treatment of hyperthyroidism with thyrostatics may cause severe hepatitis whereas untreated hyperthyroid patients are at risk of developing chronic liver failure.
背景
甲状腺毒症可能会显著改变肝功能，并与肝脏自身免疫性疾病相关。
病例报告
我们报告一例患有格雷夫斯病且经组织学确诊为胆汁淤积性肝炎的甲状腺毒症患者。甲状腺功能亢进的药物治疗使肝功能检查结果恢复正常。
结论
对于肝功能参数升高且病因不明的黄疸患者，一般应检测甲状腺功能。此外，用抗甲状腺药物治疗甲状腺功能亢进可能会导致严重肝炎，而未经治疗的甲状腺功能亢进患者有发生慢性肝衰竭的风险。
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