曼氏血吸虫四跨膜蛋白-2 基因的多态性。
Polymorphism associated with the Schistosoma mansoni tetraspanin-2 gene.
机构信息
Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA.
出版信息
Int J Parasitol. 2011 Oct;41(12):1249-52. doi: 10.1016/j.ijpara.2011.07.007. Epub 2011 Aug 22.
Abstract
A vaccine against schistosomiasis would contribute significantly to reducing the 3-70 million disability-adjusted life years lost annually to the disease. Towards this end, inoculation with the large extracellular loop (EC-2) of Schistosoma mansoni tetraspanin-2 protein (Sm-TSP-2) has proved effective in reducing worm and egg burdens in S. mansoni-infected mice. The EC-2 loop of Schistosoma japonicum TSP-2, however, has been found to be highly polymorphic, perhaps diminishing the likelihood that this antigen can be used for vaccination against this species. Here, we examine polymorphism of the EC-2 of Sm-TSP-2 in genetically unique worms derived from six individuals from Kisumu, Kenya.
摘要
一种针对血吸虫病的疫苗将大大有助于减少每年因该病而损失的 3000 万至 7000 万残疾调整生命年。为此，用曼氏血吸虫四跨膜蛋白 2 的大细胞外环（EC-2）接种已被证明可有效减少曼氏血吸虫感染小鼠中的蠕虫和卵负荷。然而，日本血吸虫 TSP-2 的 EC-2 环已被发现高度多态性，这可能降低了该抗原用于针对该物种的疫苗接种的可能性。在这里，我们检查了来自肯尼亚基苏木的六个个体的遗传独特蠕虫的 Sm-TSP-2 的 EC-2 的多态性。
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