Center for Addiction Research, Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany.
J Psychopharmacol. 2011 Nov;25(11):1480-4. doi: 10.1177/0269881111411332. Epub 2011 Sep 2.
Preclinical study results suggest that brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) are involved in the modulation of addictive behaviour. We investigated alterations in serum levels of BDNF and GDNF in opiate-dependent patients (28 males) who received diacetylmorphine treatment within a structured opiate maintenance programme. BDNF (T = 2.735, p = 0.009) serum levels were significantly increased in the opiate-dependent patients as compared with healthy controls (21 males), whereas GDNF serum levels (T = 1.425, p = 0.162) did not differ significantly from GDNF serum levels of the healthy controls. BDNF serum levels were significantly associated with craving for heroin (measured by the Heroin Craving Questionnaire (r = 0.420, p = 0.029) and by the General Craving Scale (r = 0.457, p = 0.016), whereas GDNF serum levels were not associated with psychometric dimensions of heroin craving. In conclusion, our results show a positive association between BDNF serum levels and opiate craving in opiate-dependent patients.
临床前研究结果表明，脑源性神经营养因子（BDNF）和胶质细胞源性神经营养因子（GDNF）参与了成瘾行为的调节。我们研究了在接受结构化阿片类药物维持治疗方案的阿片类药物依赖患者（28 名男性）中，BDNF 和 GDNF 的血清水平变化。与健康对照组（21 名男性）相比，阿片类药物依赖患者的血清 BDNF 水平（T = 2.735，p = 0.009）显著升高，而 GDNF 血清水平（T = 1.425，p = 0.162）与健康对照组的 GDNF 血清水平无显著差异。BDNF 血清水平与海洛因渴求显著相关（通过海洛因渴求问卷（r = 0.420，p = 0.029）和一般渴求量表（r = 0.457，p = 0.016）测量），而 GDNF 血清水平与海洛因渴求的心理测量维度无关。总之，我们的结果表明，BDNF 血清水平与阿片类药物依赖患者的阿片类药物渴求之间存在正相关。
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