Nat Cell Biol. 2011 Sep 2;13(9):1026-7. doi: 10.1038/ncb2334.
The mitochondrial network fragments during mitosis to allow proper segregation of the organelles between daughter cells. Two mitotic kinases, the cyclin B-CDK1 complex and Aurora A, are now shown to cooperate with the small G protein RALA and its effector RALBP1 to promote DRP1 phosphorylation and mitochondrial fission.
线粒体网络在有丝分裂期间发生片段化,以确保细胞器在子细胞之间的正确分离。现在已经表明,两种有丝分裂激酶,即周期蛋白 B-CDK1 复合物和 Aurora A,与小 G 蛋白 RALA 及其效应因子 RALBP1 合作,促进 DRP1 磷酸化和线粒体分裂。