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[使用单克隆抗体对肺腺癌进行免疫组织学研究]

[Immunohistological study of pulmonary adenocarcinoma using monoclonal antibodies].

作者信息

Pugachev K K, Egorova S G, Vial'tsev N V, Shimbireva I B, Kokhanova I D

出版信息

Vopr Onkol. 1990;36(4):421-4.

PMID:2189266
Abstract

Immunohistochemical methods were used to identify A2F4 monoclonal antibodies raised by immunization of animals with a human lung adenocarcinoma cell line in 17 lung adenocarcinomas and five pulmonary metastases of other origin. The antigen identified by the antibodies was registered in 53% of lung adenocarcinomas. Localization of the pulmonary antigen was compared with that of the carcinoembryonic antigen. The expression of the antigens proved different.

摘要

采用免疫组织化学方法,用人类肺腺癌细胞系免疫动物产生的A2F4单克隆抗体,对17例肺腺癌和5例其他来源的肺转移癌进行检测。抗体识别的抗原在53%的肺腺癌中表达。将肺部抗原的定位与癌胚抗原的定位进行比较。结果表明这两种抗原的表达不同。

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