NESMOS Department, Neuroradiology Faculty, Sant' Andrea Hospital, La Sapienza University, Via di Grottarossa 1035, 00189, Rome, Italy.
Radiol Med. 2012 Apr;117(3):445-60. doi: 10.1007/s11547-011-0715-4. Epub 2011 Sep 2.
Magnetic resonance imaging (MRI) with a dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI) sequence to study brain tumours provides information on the haemodynamic characteristics of the neoplastic tissue. Brain perfusion maps and calculation of perfusion parameters, such as relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV) and mean transit time (MTT) allow assessment of vascularity and angiogenesis within tumours of the central nervous system (CNS), thus providing additional information to conventional MRI sequences. Although DSC-PWI has long been used, its clinical use in the study of brain tumours in daily clinical practice is still to be defined. The aim of this review was to analyse the application of perfusion MRI in the study of brain tumours by summarising our personal experience and the main results reported in the literature.
磁共振成像（MRI）结合动态磁敏感对比灌注加权成像（DSC-PWI）序列用于研究脑肿瘤，可提供肿瘤组织的血流动力学特征信息。脑灌注图和灌注参数的计算，如相对脑血流量（rCBF）、相对脑血容量（rCBV）和平均通过时间（MTT），可评估中枢神经系统（CNS）肿瘤内的血管生成和血管生成，从而为常规 MRI 序列提供更多信息。尽管 DSC-PWI 已应用多年，但在日常临床实践中研究脑肿瘤的临床应用仍有待确定。本综述的目的是通过总结我们的个人经验和文献中报道的主要结果，分析灌注 MRI 在脑肿瘤研究中的应用。
