National Center for Chronic Disease Prevention and Health Promotion Centers for Disease Control and Prevention, Atlanta, GA, USA.
Prev Med. 2011 Oct;53(4-5):278-83. doi: 10.1016/j.ypmed.2011.08.028. Epub 2011 Aug 26.
This study was to examine the cumulative number and clustering patterns of low-risk health behaviors (i.e., not currently smoking, not excessive drinking, and physically active) associated with elevation of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT) among adults with obesity in the United States.
We estimated the age-adjusted prevalence of elevated ALT, AST, and GGT from 4547 adults with obesity aged ≥ 20 years who participated in the 2005-2008 National Health and Nutrition Examination Survey. The associations between the cumulative number or clustering patterns of low-risk health behaviors and measures of serum ALT, AST, and GGT were assessed using multivariate regression models.
Adult men who reported having three low-risk health behaviors were 62%, 39%, and 48% less likely to have elevated serum ALT, AST, and GGT, respectively; adult women were 56% and 73% less likely to have elevated serum AST and GGT, respectively, when compared to their respective counterparts who reported having none of the low-risk health behaviors.
The findings of this study indicate that, among adults with obesity, having multiple low-risk health behaviors is associated with decreased likelihoods of elevated hepatic enzymes, including ALT in men, AST and GGT in both men and women.
本研究旨在探讨美国肥胖成年人中，与血清丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）和γ-谷氨酰转移酶（GGT）升高相关的低风险健康行为（即不当前吸烟、不酗酒和身体活跃）的累积数量和聚集模式。
我们从 2005-2008 年全国健康与营养调查中，对 4547 名年龄≥20 岁的肥胖成年人进行了年龄调整后，计算了 ALT、AST 和 GGT 升高的比例。使用多变量回归模型评估了低风险健康行为的累积数量或聚集模式与血清 ALT、AST 和 GGT 之间的关联。
报告有三种低风险健康行为的成年男性，其血清 ALT、AST 和 GGT 升高的可能性分别降低了 62%、39%和 48%；与分别报告没有任何低风险健康行为的男性相比，成年女性的血清 AST 和 GGT 升高的可能性分别降低了 56%和 73%。
本研究结果表明，在肥胖成年人中，有多种低风险健康行为与降低肝脏酶升高的可能性相关，包括男性的 ALT、男性和女性的 AST 和 GGT。
