van Haren Neeltje E M, Schnack Hugo G, Cahn Wiepke, van den Heuvel Martijn P, Lepage Claude, Collins Louis, Evans Alan C, Hulshoff Pol Hilleke E, Kahn René S
Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan, the Netherlands.
Arch Gen Psychiatry. 2011 Sep;68(9):871-80. doi: 10.1001/archgenpsychiatry.2011.88.
Whether cortical thickness changes in schizophrenia over time are more pronounced relative to the changes that can be attributed to normal aging has not been studied.
To compare patients with schizophrenia and healthy control participants on cortical thickness change.
A 5-year longitudinal study comparing schizophrenic patients and healthy controls using 2 magnetic resonance images of the brain.
Patients were recruited from the Department of Psychiatry at the University Medical Centre Utrecht and from other psychiatric hospitals in the Netherlands. Healthy controls were recruited via advertisement in newspapers and notice boards.
Ninety-six schizophrenic patients and 113 healthy controls aged 16 to 56 years.
Cortical thickness and change in cortical thickness on a vertex-by-vertex basis across the cortical mantle, measures of functional and symptomatic outcome, and cumulative intake of antipsychotics during the scan interval.
At baseline, the schizophrenic patients had thinner left orbitofrontal and right parahippocampal and superior temporal cortices and a thicker superior parietal lobule and occipital pole compared with the controls. Mean cortical thickness did not differ between the groups. Over time, excessive cortical thinning was found in widespread areas on the cortical mantle, most pronounced bilaterally in the temporal cortex and in the left frontal area. Poor outcome in patients was associated with more pronounced cortical thinning. Higher cumulative intake of typical antipsychotics during the scan interval was associated with more pronounced cortical thinning, whereas higher cumulative intake of atypical antipsychotic medication was associated with less pronounced cortical thinning.
In schizophrenia, the cortex shows excessive thinning over time in widespread areas of the brain, most pronounced in the frontal and temporal areas, and progresses across the entire course of the illness. The excessive thinning of the cortex appears related to outcome and medication intake.
精神分裂症患者的皮质厚度随时间的变化相对于可归因于正常衰老的变化是否更显著，尚未得到研究。
比较精神分裂症患者与健康对照者在皮质厚度变化方面的差异。
一项为期5年的纵向研究，使用脑部的2张磁共振图像比较精神分裂症患者和健康对照者。
患者从乌得勒支大学医学中心精神病科及荷兰其他精神病医院招募。健康对照者通过报纸广告和布告栏招募。
96名年龄在16至56岁之间的精神分裂症患者和113名健康对照者。
整个皮质表面逐顶点的皮质厚度及皮质厚度变化、功能和症状结局指标，以及扫描期间抗精神病药物的累积摄入量。
在基线时，与对照组相比，精神分裂症患者的左侧眶额皮质、右侧海马旁皮质和颞上皮质较薄，而上顶叶和枕极较厚。两组之间的平均皮质厚度无差异。随着时间的推移，在皮质表面的广泛区域发现了过度的皮质变薄，最明显的是双侧颞叶皮质和左侧额叶区域。患者预后不良与更明显的皮质变薄有关。扫描期间典型抗精神病药物的累积摄入量较高与更明显的皮质变薄有关，而非典型抗精神病药物的累积摄入量较高与较不明显的皮质变薄有关。
在精神分裂症中，随着时间的推移，大脑广泛区域的皮质显示出过度变薄，在额叶和颞叶区域最为明显，并在疾病的整个过程中进展。皮质的过度变薄似乎与结局和药物摄入有关。
