Rorγt+ 先天淋巴细胞在肠道稳态和免疫中的作用。

Rorγt+ innate lymphoid cells in intestinal homeostasis and immunity.

机构信息

Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands.

出版信息

J Innate Immun. 2011;3(6):577-84. doi: 10.1159/000330668. Epub 2011 Sep 5.

Abstract

Innate lymphoid cells (ILC) combine innate and adaptive immune functions and are part of the first line of defense against mucosal infections. ILC are set apart from adaptive lymphocytes by their independence on RAG genes and the resulting absence of specific antigen receptors. In this review, we will discuss the biology and function of intestinal ILC that express the nuclear hormone receptor Rorγt (encoded by the Rorc gene) and highlight their role in intestinal homeostasis and immunity.

摘要

先天淋巴细胞（ILC）结合了先天和适应性免疫功能，是抵御黏膜感染的第一道防线的一部分。ILC 与适应性淋巴细胞不同，因为它们不依赖于 RAG 基因，因此不存在特异性抗原受体。在这篇综述中，我们将讨论表达核激素受体 Rorγt（由 Rorc 基因编码）的肠道 ILC 的生物学和功能，并强调它们在肠道稳态和免疫中的作用。