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分配救命资源——实体器官移植中的分配政策应如何评估。

Rationing life-saving resources--how should allocation policies be assessed in solid organ transplantation.

机构信息

Organ Donation and Transplantation, NHS Blood and Transplant, Bristol, UK.

出版信息

Transpl Int. 2012 Jan;25(1):3-6. doi: 10.1111/j.1432-2277.2011.01327.x. Epub 2011 Sep 8.

Abstract

Because the demand for solid organ transplantation exceeds the availability of donated grafts, there needs to be rationing for this life-saving procedures. Criteria for selection of patients to a national transplant list and allocation of donated organs should be transparent yet there is no consistent approach to the development of such guidelines. It is suggested that selection and allocation policies should comply with minimum standards including defining of aims of the allocation process and desired outcome (whether maximizing benefit or utility or ensuring equity of access), inclusion and exclusion criteria, criteria for futility and suspension and removal from the transplant list, appeals processes, arrangements for monitoring and auditing outcomes and processes for dealing with noncompliance. Furthermore, guidelines must be consistent with legislation even though this may compete with public preference. Guidelines must be supported by all stakeholders (including health-care professionals, donor families and potential transplant candidates). However, there must also be flexibility to allow for exceptions and to support innovation and development.

摘要

由于对实体器官移植的需求超过了可供捐赠的移植物的数量,因此需要对这种救命手术进行配给。选择患者进入国家移植名单和分配捐赠器官的标准应该是透明的,但在制定此类指南方面没有一致的方法。有人建议,选择和分配政策应符合最低标准,包括定义分配过程的目的和预期结果(是最大化效益还是效用,还是确保公平获得)、纳入和排除标准、无效和暂停以及从移植名单中除名的标准、申诉程序、监测和审核结果的安排以及处理违规行为的程序。此外,即使与公众的偏好相冲突,指南也必须符合立法。准则必须得到所有利益攸关方(包括医疗保健专业人员、捐赠者家庭和潜在的移植候选人)的支持。然而,也必须有灵活性,以允许例外情况,并支持创新和发展。

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